| 补体溶菌试验在霍乱杀弧菌抗体检测中的应用 |
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| 引用本文： | 栾玉明,;李少彤,;曾涛,;陈万山,;钟豪杰,;朱月娥,;卢树成. 补体溶菌试验在霍乱杀弧菌抗体检测中的应用[J]. 广东寄生虫学会年报, 2007, 0(8): 788-790 |
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| 作者姓名： | 栾玉明, 李少彤, 曾涛, 陈万山, 钟豪杰, 朱月娥, 卢树成 |
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| 作者单位： | [1]广州市海珠区疾病预防控制中心,广州510288; [2]广州市第八人民医院,广州510060; [3]广东省疾病预防控制中心,广州510300 |
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| 基金项目： | 广州市海珠区科技计划项目（No.2003-Z-50）. |
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| 摘 要： | 目的了解不同人群的霍乱杀弧菌抗体水平和对霍乱的免疫状态,并探讨补体溶菌试验检测技术的应用价值。方法采用补体溶菌试验方法检测不同人群杀弧菌抗体水平,并运用统计学方法,对补体溶菌试验与常规分离培养法的检测结果进行分析。结果确诊病人的抗体水平显著高于当地健康人群（P〈0.001）;补体溶菌试验方法与常规分离培养法检测结果差异无统计学意义（P〉0.05）。结论补体溶菌试验法在基层霍乱检测工作中具有一定的应用价值,为霍乱的免疫学和流行病学研究提供了依据。
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| 关 键 词： | 补体溶菌试验 霍乱 杀弧菌抗体 |
Detection of Cholera Vibriocidal Antibody with Complement-Mediated Bacteriolysis |
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| Affiliation: | LUAN Yu-ming, LI Shao-tong, ZENG Tao, CHEN Wan-shan, ZHONG Hao-jie, ZHU Yue-e, LU Shu-cheng (1. Haizhu Center for Disease Control and Prevention of Guangzhou, Guangzhou 510288; 2. Guangzhou No.8 People＇s Hospital, Guangzhou 510060; 3. Guangdong Center for Disease Control and Prevention, Guangzhou 510300, China) |
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| Abstract: | Objective To study the cholera vibriocidal antibody levels in different groups of people and the immunity state against cholera, and evaluate the complement-mediated bacteriolysis technique. Method The vibriocidal antibody levels in different groups of people were examined with complement-mediated bacteriolysis technique. Cholera specimens were detected with two methods and analyzed by statistics. Result The results indicated that the antibody levels in patient group were significantly higher than those in healthy people group （P 〈 0.001 ）. The difference between the complement-mediated bacteriolysis technique and the conventional method had no statistical significance （P〉 0.05）. Conclusion The complement-mediated bacteriolysis technique is useful for detection of cholera infection and state of infection. It can provide a basis for the immunological and epidemiological study of cholera. |
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| Keywords: | complement-mediated bacteriolysis cholera vibriocidal antibody |
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