| 酒石酸美托洛尔片假药的鉴别 |
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| 引用本文： | 魏宁漪,周颖,余振喜,李婕,施亚琴.酒石酸美托洛尔片假药的鉴别[J].药物分析杂志,2011(2). |
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| 作者姓名： | 魏宁漪 周颖 余振喜 李婕 施亚琴 |
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| 作者单位： | 中国药品生物制品检定所; |
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| 摘 要： | 目的:鉴别酒石酸美托洛尔片中的掺假成分。方法:采用HPLC-MS/MS和HPLC-DAD方法对样品中的掺假成分进行分析检测。结果:样品中的掺假成分鉴定为氯霉素,抽样的2批标示为酒石酸美托洛尔片样品中,未含酒石酸美托洛尔而含有氯霉素。结论:由于氯霉素的紫外光谱图和化学反应现象与酒石酸美托洛尔相似,故极少数据采用氯霉素冒充酒石酸美托洛尔生产假药。
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| 关 键 词： | 酒石酸美托洛尔片 氯霉素 HPLC-MS/MS HPLC-DAD |
Identification of counterfeit metoprolol tartreate tablets |
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| WEI Ning-yi,ZHOU Ying,YU Zhen-xi,LI JIE,SHI Ya-qin.Identification of counterfeit metoprolol tartreate tablets[J].Chinese Journal of Pharmaceutical Analysis,2011(2). |
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| Authors: | WEI Ning-yi ZHOU Ying YU Zhen-xi LI JIE SHI Ya-qin |
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| Affiliation: | WEI Ning-yi,ZHOU Ying,YU Zhen-xi,LI JIE,SHI Ya-qin(National Institute for the Control of Pharmaceutical and Biological Products,Beijing 100050,China) |
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| Abstract: | Objective:To identify an unknown component in counterfeit metoprolol tartreate tablets.Methods:To identify the unknown component in samples marked metoprolol tartreate tablets by the high performance liquid chromatography-quadrupole mass spectrometry and HPLC-DAD method.Results:The unknown component in samples marked metoprolol tartreate tablets is not metoprolol tartreate but chloramphenicol.Conclusion:Chloramphenicol illegally added into the metoprolol tartreate tablets to substitute metoprolol tartreate ... |
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| Keywords: | metoprolol tartreate tablets chloramphenicol HPLC-MS/MS HPLC-DAD |
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