1997～2001年四川省川崎病流行病学调查

目的了解四川省川崎病(KD)的发病率和流行病学特点。方法按日本川崎病研究中心提供的川崎病诊断标准、问卷表格和调查方法,对四川省内设有儿科病床的医院进行问卷调查。收集1997年1月1日～2001 年12月31日的川崎病患儿住院资料。结果调查全省212所医院,调查表回收率达到91．5％,全省共报告了KD 患儿1811例,符合川崎病诊断标准1511例。1997～2001年<5岁儿童患病率分别为4．26／10万、5．21／10万、8．57／ 10万、7．70／10万、9．81／10万,5年平均发病率为7．06％。男女之比为1．66:1,发病高峰为1～2岁,17．0％的川崎病患儿有心脏冠脉损伤。典型病例占94．6％,使用静脉丙种球蛋白(IVIG)治疗者占70．9％。结论 1997～2001年四川省5年川崎病的发病率低于日本,与国内其他地区KD流行病学资料相比,发病率高于江苏、陕西和广东,低于北京,有逐年增高趋势。

Epidemiological investigation of Kawasaki disease during 1997～2000 in Sichuan Province

Objective To investigate the incidence and the epidemiological characteristics of Kawasaki disease (KD) in Sichuan province of China. Methods Based on the diagnostic criterion of Kawasaki disease provided by the Japan Kawasaki Disease Research Center (JKDRC), all hospitals with the department of pediatrics in Sichuan province were enrolled the investigation of KD with the way of questionnaire from January 1, 1997 to December 31, 2001. Results 91.5% of questionnaire was returned and 1811 children with KS came from 212 hospitals were reported in the investigation. 1511 cases of them agreed with the criterion of KD. The incidences of KD were 4. 26 (1997), 5.21 (1998), 8.57 (1999), 7.70 (2001), 9.81 (2001) per 100,000 children under 5 years old, and the average incidence was 7.06 per 100,000 in the period of 5 years. The ratio of male to female was 1. 66: 1 and the age distribution pattern showed a peak near 1-2 year old. The coronary artery damage was seen in 17.0% of the patients with KD. The typical cases were about 94.6% of total cases. There were 70.9% of the patients with KD to be treated with IVIG. Conclusions The incidence of KD in Sichuan province was lower than that in Japan and Beijing, and higher than those in Guangdong, Jiangsu and Shanxi provinces of China. However, the incidence of KD seems to be with an ascending trend year by year.