内皮抑素与子宫内膜异位症相关研究进展

内皮抑素是目前已知最强的内源性血管生成抑制因子,它对以肿瘤血管为代表的活跃增殖的血管内皮细胞有强烈的选择性抑制作用,且无毒性、无耐药性,能明显对抗肿瘤的进行性生长.子宫内膜异位症的发生和进展与肿瘤类似,存在明显的新生血管依赖性,抑制异位血管增生被认为是治疗子宫内膜异位症的有效途径,从上提示,内皮抑素可能成为治疗子宫内膜异位症的有效药物.该文将结合内皮抑素的结构特点,围绕其抑制新生血管生成的作用机制,着重对其可能用于子宫内膜异位症诊断及治疗方面的相关研究进展作以综述.

Advances in research on relationship between endostatin and endometriosis

Endostation is the most potentest(strongest)endogeneous angiogenisis inhibor and specifically inhibits endothelial proliferation represented by tumor Vessels.It is untoxic and unresistant to drugs and can signifecantly inlibit the progressive tumorinduced angiogenesis, resulting in a strong antitumor activity.Similar to tumor,the occurrance and development of endometriosis(EMs)is angiogenesis- independent,So inkibiting ectopic angiogenesis of endometrum is considered an effective approach to treat EMs.It is suggested endostatin will become an effective drug for EMs.In this article,we reviewed the relevant researches on the diagnosis and treatment of EMs,as well as its structural characteristics,mechanism of action of endostatin for inhibiting the angiogenesis.