| 一种铜催化合成异吲哚啉-1-酮的方法 |
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| 引用本文： | 李鹏程,张胜,包明. 一种铜催化合成异吲哚啉-1-酮的方法[J]. 分子科学学报, 2020, 0(1): 8-15,I0001 |
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| 作者姓名： | 李鹏程 张胜 包明 |
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| 作者单位： | 大连理工大学精细化工国家重点实验室;大连理工大学石油与化学工程学院 |
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| 基金项目： | 国家自然科学基金青年基金资助项目(21602026);中央高校基本科研业务费专项资金资助项目(DUT18RC(4)043)。 |
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| 摘 要： | 本文设计了一种以邻苯甲腈和苯乙炔为原料,在铜催化剂的作用下环化生成异吲哚啉-1-酮的反应方法.以邻溴苯腈和苯乙炔作为反应模板,对溶剂、碱添加剂、催化剂、反应时间和温度做了探索,确定最佳反应条件为:碘化亚铜(0.02 mmol),去氧水(0.6 mmol),叔丁醇钾(0.3 mmol),1,4-二氧六环(0.2 mol·L^-1),100℃反应6 h.在最优反应条件下,对不同的反应底物进行了一系列的研究,底物适用性良好.
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| 关 键 词： | 异吲哚啉-1-酮 铜催化 环化反应 一锅法 |
A method for Cu-catalyzed synthesis of isoindolin-1-ones |
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| LI Peng-cheng,ZHANG Sheng,BAO Ming. A method for Cu-catalyzed synthesis of isoindolin-1-ones[J]. Journal of Molecular Science, 2020, 0(1): 8-15,I0001 |
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| Authors: | LI Peng-cheng ZHANG Sheng BAO Ming |
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| Affiliation: | (State Key Laboratory of Fine Chemicals,Dalian University of Technology,Dalian 116023,China;School of Petroleum and Chemical Engineering,Dalian University of Technology,Panjin 124221,China) |
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| Abstract: | In this paper,a reaction method for Cu-catalyzed cyclization of isoindoline-1-one with 2-benzonitrile and phenylacetylene as raw materials was designed.Using 2-bromobenzonitrile and phenylacetylene as reaction templates to explore the solvent,base additive,catalyst,reaction time and temperature to determine the optimal reaction conditions:CuI(0.02 mmol)and H2O(0.6 mmol),KOtBu(0.3 mmol),1,4-dioxane(0.2 mol·L^-1),reacted at 100°C for 6 h.Under the optimal reaction conditions,a series of substrates were researched and showed good applicability. |
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| Keywords: | isoindolin-1-ones Cu-catalyzed cyclization one-pot method |
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