| 桑白皮总黄酮的镇咳祛痰作用 |
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| 引用本文： | 韦媛媛,徐 峰,陈 侠,陈晓伟,张国刚.桑白皮总黄酮的镇咳祛痰作用[J].沈阳药科大学学报,2009,26(8):644-647. |
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| 作者姓名： | 韦媛媛 徐 峰 陈 侠 陈晓伟 张国刚 |
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| 作者单位： | 1. 广西工学院 生物与化学工程系，广西 柳州 545006； 2. 沈阳药科大学 药学院，辽宁 沈阳110016；3. 沈阳药科大学 中药学院，辽宁 沈阳110016 |
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| 摘 要： | 目的研究桑白皮总黄酮镇咳祛痰作用。方法采用浓氨水、SO2小鼠引咳法,小鼠气管酚红排泌及大鼠气管毛细管分泌液模型,观察桑白皮黄酮的镇咳祛痰作用。结果125 mg.kg-1显著抑制浓氨水、SO2所致小鼠咳嗽潜伏期,减少氨水引咳次数,桑白皮总黄酮250 mg.kg-1显著减少SO2引咳次数。桑白皮总黄酮125 mg.kg-1增加小鼠气管酚红排泌,桑白皮总黄酮180 mg.kg-1显著增加大鼠气管分泌液。结论桑白皮总黄酮具有镇咳祛痰作用。
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| 关 键 词： | 桑白皮 黄酮 镇咳 祛痰 |
| 收稿时间： | 2008-10-27 |
Antitussive and expectorant effects of the flavonoid of Cortex Mori |
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| WEI Yuan-yuan,XU Feng,CHEN Xia,CHEN Xiao-wei,ZHANG Guo-gang.Antitussive and expectorant effects of the flavonoid of Cortex Mori[J].Journal of Shenyang Pharmaceutical University,2009,26(8):644-647. |
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| Authors: | WEI Yuan-yuan XU Feng CHEN Xia CHEN Xiao-wei ZHANG Guo-gang |
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| Affiliation: | 1. Department of Biological and Chemical Engineering, Guangxi University of Technology, Liuzhou,545006, China; 2. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China; 3. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China |
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| Abstract: | Objective To study the antitussive and expectorant effects of the flavonoid of Cortex Mori (FCM). Methods The cough models were induced by ammomia and SO2 in mice, respectively. The excretory amount of sputum was determined by phenolsulfonphthalein excretion method in mice and the liquid excretion quantity of the airway in rats, respectively. Results The latency of cough induced by ammonia and SO2 in mice was significantly prolonged by FCM 125 mg·kg –1, and the number of cough was significantly diminished by FCM 125 mg·kg –1 in ammonia induced mice model and FCM 250 mg·kg –1 in SO2 induced mice model, respectivly.The phenolsulfonphthalein excretion quantity of tracheal in mice and the liquid secretion from the airway in rats were increased by FCM. Conclusion FCM had antitussive and expectorant effect. |
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| Keywords: | Cortex Mori flavonoid antitussive expectorant |
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