| Relationship belween Gene Expression of bFGF and Prolifercrtive Activity in Meningioma |
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| 摘 要： |
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| 关 键 词： | 基因表达 bFGF 脑脊膜瘤 治疗方法 病理机制 |
| 收稿时间： | 2005-06-25 |
| 修稿时间： | 2005-09-12 |
Relationship between gene expression of bFGF and proliferative activity in meningioma |
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| Zhongqiu Luo, Jinhuan Wang, Peiyu Pu, Xinnu Xu, Youping Zhang, Hongsheng Liu, Ping Liu, Jianbing Qi and Mu Li. Relationship between gene expression of bFGF and proliferative activity in meningioma[J]. Chinese Journal of Clinical Oncology, 2005, 2(5): 805-809. DOI: 10.1007/BF02772881 |
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| Authors: | Zhongqiu Luo Jinhuan Wang Peiyu Pu Xinnu Xu Youping Zhang Hongsheng Liu Ping Liu Jianbing Qi Mu Li |
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| Affiliation: | (1) Department of Neurosurgery, Tianjin First Central Hospital, 300192 Tianjin, China;(2) Department of Neurosurgery, Tianjin Medical University General Hospital, 300052 Tianjin, China;(3) Department of Intensive Laboratory, Tianjin First Central Hospital, 300192, China;(4) Department of Nuclear Medicine, Tianjin First Central Hospital, 300192, China;(5) Department of Clinical Laboratory, Tianjin First Central Hospital, 300192, China |
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| Abstract: | Objective To study the relationship between bFGF gene expression and proliferative activity in meningiomas. Methods Thirty-seven samples of meningioma were examed using Northern hybridization for bFGF-gene expression and immunohistochemistry for bFGF protein expression and the Ki-67LI. Results bFGF mRNA was detected in 22 meningiomas of Grade I and in all samples of Grade II and III. Six of the Grade I tumors were negative, giving an overall positive rate of 83.8 % for bFGF mRNA. Autoradiography was conducted using a thin scaning apparatus. bFGF mRNA expression compared to that for β-actin was 0.34±0.06 for Grade I tumors compared to 0.82±0.12 for Grade II and III tumors. The difference was highly significant (P<0.001). The results of immunohistochemistry showed that the number of the positive cells for the bFGF protein was 29.7±7.6% in Grade I tumors and 63.2±11.7 % in Grade II plus III, resulting in a significant difference between them (P<0.001). The Ki-67LI was found to be 2.8+1.1 % in Grade I and 6.5±1.3 % in Grade II plus III. The former was significantly lower than the later (P<0.001). Conclusion The expression of bFGF was correlated well with the malignancy of the meningiomas. |
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| Keywords: | meningioma bFGF Ki-67LI. |
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