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In vitro antiviral effect of flavonoid-rich extracts of Vitex polygama (Verbenaceae) against acyclovir-resistant herpes simplex virus type 1 |
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| Authors: | JLS Gonalves SG Leito F Delle Monache MMFS Miranda MGM Santos MTV Romanos MD Wigg |
| Affiliation: | aInstituto de Microbiologia Professor Paulo de Góes, Departamento de Virologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil bDepartamento de Produtos Naturais e Alimentos, Faculdade de Farmácia, CCS, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil cCentro Chimica dei Recettori del C.N.R., Università Cattolica del Sacro Cuore, Istituto di Chimica, Roma, Italy |
| Abstract: | Extracts and fractions rich in flavonoids from fruits and leaves of Vitex polygama Cham. (Verbenaceae) were tested against acyclovir-resistant herpes simplex virus type 1 (ACVR-HSV-1). Both fruit and leaf extracts exhibited a dose-dependent antiviral activity. The extract from the leaves showed intracellular antiviral activity while the extract from the fruits had virucidal effect. A fraction from the ethyl actetate extract of the leaves inhibited virus propagation by blocking HEp-2 cell receptors. |
| Keywords: | antiviral activity virucidal HEp-2 cells acyclovir-resistant HSV-1 flavonoids Vitex polygama Verbenaceae |
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