内蒙古某地区男性超重肥胖和饮酒对血尿酸的影响

目的了解内蒙古某地区男性超重肥胖和饮酒对血尿酸（SUA）水平的影响。方法2006年9月至2007年3月，抽取在锡林郭勒盟医院健康体检的630名城区男性和179名农区男性为调查对象进行横断面调查，通过问卷调查、体格检查和实验室检测分别获取调查对象饮酒、身高、体重、腰围和SUA水平，按照日均饮酒量、过量饮酒频次、饮酒种类定义饮酒情况，通过体质指数（BMI）和腰围反映超重或肥胖和中心型肥胖，采用协方差分析、多因素logistic回归分析，探讨超重肥胖和饮酒对SUA的影响及其之间的交互作用。结果体重正常组、超重组、肥胖组的SUA水平依次升高，分别为（315．6±81．0）、（350．4±81．6）、（376．8±82．2）μmol／L，差异有统计学意义（P〈0．01）；超重和肥胖组的高尿酸血症（HUA）的检出率分别为19．5％、33．1％，高于正常体重组（8．3％），调整后的OR值分别为2．71（95％CI：1．68～4．39）和5．47（95％C1：3．31～9．04）。超量饮酒者SUA水平[（360．6±85．8）μmol／L]高于从不饮酒者和适量饮酒者[分别为（317．4±93．0）、（343．2±78．6）μmol／L]，差异均有统计学意义（P〈0．05）；每周过量饮酒1—2次者的SUA水平[（355．2±81．0）μmol／L]高于从不饮酒者和饮酒但从不过量者[（334．2±78．0）μmol／L]，差异均有统计学意义（心0．05）。中心型肥胖且超量饮酒者HUA的患病危险高，OR值为3．46（95％CI：1．65—7．25）。未发现超重或肥胖和饮酒对SUA水平影响的交互作用。结论超重或肥胖是HUA的独立危险因素，过量饮酒会导致SUA水平的升高。建议我国北方男性控制或降低体重，限制饮酒，以预防HUA和痛风的发生。

The effects of overweight,obesity and drinking on serum uric acid in male residents of Inner Mongolian

Objective To investigate the effects of overweight, obesity and drinking on serum uric acid （SUA） in male residents of Inner Mongolian. Methods A cross-sectional study with 809 males was conducted in Xilingol of Inner Mongolia during September 2006 to March 2007. The data of drinking, height, weight, waistline and SUA levels were collected by self-design questionnaire, physical and lab examinations. The subjects were divided into normal-weight and overweight group according to BMI. In addition, the participants were divided into three subgroups on the basis of ethanol consumption. Multivariate analysis of variance and logistic regression analysis were used to assess effects of overweight, obesity and drinking on SUA and hyperuricemia （SUA〉420 p, mol/L）. Results The SUA levels in overweight （24 kg/m2≤BMI〈 28 kg/m2） group and obesity group （BMI≥28 kg/m2） were （350.4±81.6） and （376.8±82.2） μmol/L, respectively, which were significantly higher than that [（315.6±81.0）μmol/L] in normal- weight group （P〈0.01）. The detected rates of HUA in overweight and obesity groups were 19.5% and 33.1%, which were significantly higher than that （8.3%） in normal weight group （OR=2.71, 95%CI： 1.68-4.39,OR=5.47, 95%CI： 3.31-9.04）. The SUA level [（360.6±85.8） μmol/L] of drinkers （alcohol consummation〉25 g/d） was significantly higher than that [（311.4±93.0）μmol/L] of non-drinkers and that [（343.2±78.6） μmol/L] of moderate drinkers （alcohol consummation〈25 g/d） （P〈0.05）. The SUA level [（355.2±81.0） μmol/L] of drinkers （over drinking 1-2 times in a week） was significantly higher than those [（317.4±93.0）, （334.2±78.0） μmol/L）] of non-drinker and moderate drinkers （P〈0.01）. The risk of hyperuricemia （HUA） in over drinkers with abdominal obesity （waistline〉90 cm） significantly enhanced （OR=3.46, 95%CI： 1.65-7.25）. The interaction of overweightobesity on SUA level was not found. Conclusion Overweight or obesity are the independent risk factors of hypernricemia. Over consumption alcohol could increase SUA level. It is suggested that the male residents in northern China should control the weight and drinking for preventing HUA and gout.