| 归芪合剂联合缬沙坦对2型糖尿病大鼠肾脏功能的保护作用 |
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| 引用本文： | 刘红,唐建平,陈武宁,张团笑,敬华娥.归芪合剂联合缬沙坦对2型糖尿病大鼠肾脏功能的保护作用[J].中国现代药物应用,2009,3(11):1-2. |
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| 作者姓名： | 刘红 唐建平 陈武宁 张团笑 敬华娥 |
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| 作者单位： | 四川省南充市川北医学院,637100 |
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| 基金项目： | 四川省教育厅科学研究项目，南充市重点科技项目 |
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| 摘 要： | 目的研究归芪合剂联合缬沙坦对2型糖尿病（T2DM）大鼠肾脏功能的保护作用。方法建立T2DM大鼠模型，给予归芪合剂联合缬沙坦灌胃治疗12周，测定大鼠空腹血糖（FBG）、血脂（TG）、总胆固醇（TC）、超氧化物歧化酶（SOD）、丙二醛（MDA）的水平；测定胰岛素敏感指数（ISI）、肾脏肥大指数（KW／BW）和肾皮质钠钾．ATP酶活性。结果①与正常对照组比较，T2DM模型组大鼠FBG、TG、TC、MDA和KW／BW显著升高，SOD、ISI和肾皮质钠钾．ATP酶活性显著降低（P〈0．01 or P〈0．05）；②与T2DM模型组比较，治疗组大鼠FBG、TG、TC、MDA和KW／BW显著降低，SOD、ISI和肾皮质钠钾-ATP酶活性显著升高（P〈0．01）。结论归芪合剂联合缬沙坦对T2DM大鼠肾脏功能具有明显保护作用。
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| 关 键 词： | 归芪合剂 缬沙坦 2型糖尿病 肾脏功能 保护 |
Protection of Guiqi liquid & Valsartan on the renal function in the type 2 diabetic rats |
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| Affiliation: | LIU Hong , TANGJian-ping, CHEN Wu-ning, et al.( Department of Physiology, North Sichuan Medical College, Nanchong 637100, China) |
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| Abstract: | Objective To investigate the protection of Guiqi liquid ＆ Valsartan on the renal function in the type 2 diabetic rats. Methods The diabetes rats were received Guiqi liquid ＆ Valsartan for 12 weeks. The following parameters were measured ： FBG, TG, TC, KW/BW, ISI, SOD, MDA and sodium pump activity of renal cortex. Results Compared to model controls, TG, TC, MDA level and KW/BW in the treat group rats were significantly decreased;SOD, ISI and sodium pump activity of renal cortex were significantly increased （P 〈 0. 01 or P 〈 0. 05 ）. Conclusion Guiqi liquid ＆ Valsartan can defend renal function in T2DM rats. |
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| Keywords: | Guiqi liquid Valsartan Type 2 diabetes mellitus Kidney function Protection |
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