明胶/羟基磷灰石复合物微球中明胶对无机相影响的研究

在油包水的乳液体系中,通过原位合成的方法使羟基磷灰石(HAP)在明胶链上化学沉积,改变明胶溶液的浓度,制得了一系列的明胶/HAP复合物微球.采用X射线衍射仪(XRD)、傅里叶变换红外光谱仪(FTIR)、扫描电子显微镜(SEM)、透射电子显微镜(TEM)和热失重分析仪(TGA)等对产物的组成、形貌以及热失重情况进行了表征.结果表明,明胶用量对复合物微球中HAP的形成具有重要影响.在明胶溶液浓度为0.025 g/mL时,明胶分子链提供的结合位点恰好与溶液中游离的Ca²⁺、PO₄^3-等离子达到平衡状态,复合物微球中无机相含量达40%,这是明胶与HAP以化学键合的形式结合所能得到的最大值.

Studies on Hydroxyapatite Formation in Gelatin/Hydroxyapatite Composite Microspheres

By changing the concentration of gelatin solutions,a series of Gelatin/Hydroxyapatite(HAP) composite microspheres were prepared through in-situ synthesis method in water-in-oil(w/o) emulsions.The products were characterized by X-ray diffraction(XRD),scanning electron microscopy(SEM),transmission electron microscopy(TEM) and thermal gravimetric analysis(TGA).The experimental results indicated that the concentration of gelatin solutions had great influence on the formation of HAP.When the gelatin concentrations were lower than 0.025 g/mL,the formation amount of HAP increased with the increase of gelatin dosage.Once the gelatin concentrations were more than 0.025 g/mL,the formation amount of HAP decreased and the crystal form became poor with the increase of gelatin dosage.In conclusion,the binding of gelatin and HAP had a maximum value at gelatin concentration around 0.025 g/mL.