| The diagnostic value of neuron specific enolase in patients with gliomas |
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| 引用本文： | 费舟,章翔,宋少军,顾建文,陈名声. The diagnostic value of neuron specific enolase in patients with gliomas[J]. 中国人民解放军军医大学学报, 1999, 0(1) |
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| 作者姓名： | 费舟 章翔 宋少军 顾建文 陈名声 |
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| 作者单位： | Department of Neurosurgery，Xijing Hospital Fourth Military Medical University，Xi'an. 710032 |
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| 摘 要： | Effectivetreatmentofgliomashasbeenhamperedbyourinabilitytodefinebiologiccharacteristicsofgliomas.Identificationofcytosolorcellsurfacemarkerswithbiologicaleffectsthaiaretissueand/ortumorspecificmayresultinimprovedtreatment.Asoneoffoemostinlporlanlbiologicalenzymesinglucolyslsandnewlyfoundtumormarkers,neuronspecificenolase(qSE)ismainlypresentedincen[rafnervoLlssystem.Alpresent.researchesonQSEchangesingliomasarelimitedtobasicaspectssuchasimnlunochenlicalanalysis1.2andlittleatlentionispaidicfoed…
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The diagnostic value of neuron specific enolase in patients with gliomas |
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| Fei Zhou, Zhang Xiang, Song Shaojun , Gu Jianwen, ChenMingsheng. The diagnostic value of neuron specific enolase in patients with gliomas[J]. Journal of Medical Colleges of PLA(China), 1999, 0(1) |
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| Authors: | Fei Zhou Zhang Xiang Song Shaojun Gu Jianwen ChenMingsheng |
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| Abstract: | Objective: In order ic look into the alterations and effects of neuron specific enolase (NSE) in cerebralspinal fluid (CSF ) and serum of foe paticnts with glioma and meningiomas. Methods: We studied CSF and serumlevels of NSE in 40 patients with gliomas and 10 with meningiomas;3 days before and after operation byradioimmunoassay. Results: Compared with the value of NSE: in CSF and serum from 10 control patients. samplesfrom patients with malignant gliomas contained abnormally high level of NSE before operation (P < 0. 05 ) butnormal level after operation (P >0. 05 ). However. samples from patients with low grade gliomas andmeningiomas were within normal range before and after operation (P >0. 05). Gliomas with totall refectionshowed normal NSE values but with sub lotal removal presented high levels of NSE after surgery (P < 0. 05).Conclusion: The increased value of NSE in patients with malignant gliomas may be associated with elevated rate of glucolysis. As one of the new tumor markers NSE Is postulated to play an important role in the diagnosi followup and monitoring of gliomas. |
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| Keywords: | brain tumor glioma /diagnosis meningioma: nenron specific enolase |
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