Hemoglobin adducts of benzo[a]pyrene diolepoxide in newspaper vendors: association with traffic exhaust期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Hemoglobin adducts of benzo[a]pyrene diolepoxide in newspaper vendors: association with traffic exhaust

Authors:	Pastorelli, Roberta Restano, Jolanda Guanci, Marco Maramonte, Monica Magagnotti, Cinzia Allevi, Riccardo Lauri, Davide Fanelli, Roberto Airoldi, Luisa

Affiliation:	Laboratory of Molecular Toxicology, Istituto di Ricerche Farmacologiche Mano Negri Via Eritrea 62, 20157 Milan, Italy ¹General Practice Research Unit, Istituto di Ricerche Farmacologiche Mano Negri Via Eritrea 62, 20157 Milan, Italy ²Laboratory of Environmental Pharmacology and Toxicology, Istituto di Ricerche Farmacologiche Mano Negri Via Eritrea 62, 20157 Milan, Italy

Abstract:	Benzo[a]pyrene diol epoxide adducts with hemoglobin (Hb) weremeasured to detect human exposure to environmental benzo[a]pyrenefrom traffic exhaust. Benzo[a]pyrene tetrahydrotetrols (BPTs)released from Hb after acid hydrolysis were quantitated by gaschromatography-mass spectrometry after immunoaffinity chromatography.Fifty three newspaper vendors were enrolled. The median adductconcentration was 0.3 fmol BPTs/mg Hb in high density traffic-exposedvendors and

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