急性心肌梗死患者血浆脑钠素浓度的变化及其临床意义

目的：探讨急性心肌梗死（AMI）后血B型利钠肽（BNP）水平的变化及其临床意义。方法：顺序入选2010年1月至2011年10月在我院CCU病房住院的AMI患者200例，其中ST段抬高型心肌梗塞（STEMI）135例为STEMI组，非ST段抬高型心肌梗塞（NsTEMI）65例为NSTEMI组；另选择有心绞痛或冠状动脉无狭窄的患者110例作为心绞痛及正常对照组。采用美国博适公司Triage型BNP定量诊断仪测定BNP浓度。结果：①AMI组BNP浓度明显高于心绞痛及正常对照组（467±645）pg／ml比（29±50）pg／mi，P〈0．01]；②不同类型的心肌梗死（STEMI和NSTEMI）之间BNP水平无明显差异（586±574）ng／ml比（460±435）ng／ml，P〉0．051。结论：检测B型利钠肽浓度对急性心梗患者的诊断、治疗有重要的临床意义。

Change of plasma level of brain natriuretic peptide in patients with acute myocardial infarction and its clinical significance

Objective： To explore change of blood level of B type natriuretic peptide （BNP） after acute myocardial in-farction （AMI） and its clinical significance. Methods： A total of 200 AMI patients admitted in our CCU wards from Jan 2010 to Oct 2011 were consecutively enrolled and regard as AMI group, including 135 cases with ST-segment ele-vation myocardial infarction （STEMI group） and 65 cases with non ST-segment elevation myocardial infarction （NSTEMI group） ; another 110 cases with angina pectoris or no coronary artery stenosis were regard as angina pec-torts and normal control group. The BNP concentration was measured. Results： ① Compared with angina pectorts and normal control group, there was significant increase in BNP concentration （29 ± 50） pg/ml vs. （467± 645） pg/ ml] in AMI group, P〈0.01;② There was no significant difference in BNP level between STEMI and NSTEMI （586 ± 574） ng/ml vs. （460 ± 435） ng/ml, P〉0.05]. Conclusion： Detection of concentration of B type natriuretic peptide possesses important clinical significance for diagnosis and treatment of patients with acute myocardial infarction.