冠心病与谷胱甘肽过氧化物酶1基因Pro200Leu多态性

目的探讨GPX1基因Pro200Leu多态性与冠心病的关系。方法采用病例对照研究方法,收集早发冠心病患者375例,迟发冠心病患者519例,对照334人,采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)基因分型技术对GPX1基因Pro200Leu多态性进行检测,采用logistic回归计算Pro200Leu多态性与冠心病风险的比值比(OR值)和95%可信区间(CI)。结果与对照组相比,早发冠心病组携带CT+TT基因型的个体比携带CC基因型更容易患冠心病,多因素调整后,OR=1.96(95%CI=1.17-3.31);迟发冠心病组与对照组相比较,多因素调整后则无统计学意义(OR=1.75,95%CI=0.76-4.02)。结论 GPX1基因Pro200Leu多态性T等位基因可能是早发冠心病的一个危险因素。

Association of GPX1 gene Pro200Leu polymorphism with coronary artery disease

Objective To investigate the relationship between GPX1 gene Pro200Leu polymorphism and coronary artery disease(CAD).Methods A hospital-based case-control study was conducted on 375 premature CAD,519 late-onset CAD patients and 334 controls with polymerase chain reaction restriction fragment length polymorphism(PCR-RFLP) to detect the polymorphism.Logistic regression models were performed to estimate the odds ratios(ORs) with 95% confidence intervals(CIs).Results The odds ratio of CT+TT versus CC genotype of Pro200Leu polymorphisms with CAD between the early-onset CAD group and controls was statistically significant in the multiple logistic model(OR: 1.96,95%CI: 1.17-3.31).For the comparison between the late-onset CAD group and controls,the odds ratio became not significant after adjusting the potential confounders(OR: 1.75,95%CI: 0.76-4.02).Conclusion The T allele of GPX1 gene Pro200Leu polymorphism may be a risk factor in early-onset CAD.