逍遥散在肝损伤模型大鼠体内的药效学和药动学研究

目的 研究逍遥散降酶的药效学、药动学过程，为合理用药提供参考。方法 大鼠sc含40% CCl₄的橄榄油溶液2 mL/kg，每2天1次，首次给药4 mL/kg，连续12 d。以天冬氨酸转氨酶（AST）降低量为药效学指标，进行逍遥散的药效学研究；通过PKSolver 2.0统计距分析求算相关药动学和药效学参数。结果 逍遥散的降酶时-效曲线具有显著的双峰特性，其t_d、t_1/2（ED）、AUC、MRT分别为17.79 h、3.73 h、657.07 U?L^?1?h、6.23 h。结论 逍遥散在肝损伤大鼠体内具有吸收快，消除慢，作用维持时间较长的特点。

Pharmacodynamic and pharmacokinetic study on reducing enzyme by Xiaoyao Powder used for liver-injured rats in vivo

Objective To carry out the pharmacodynamic and pharmacokinetic study on the reducing enzyme of Xiaoyao Powder and provide reference for the rational using drug. Methods The liver-injured rat model was developed by sc injection of 2 mL/kg olive oil solution with 40% CCl₄ every two days for 12 d by frist administration of 4 mL/kg. With the decrease in aspartate amino transferase (AST) as the parameter, the pharmacodynamics of Xiaoyao Powder was studied. The apparent parameters of pharmacodynamics and pharmacokinetics were estimated based on the time-effect curve by PKSolver 2.0. Results The time-effect curve of reducing enzyme by Xiaoyao Powder was characterized by double peaks and could be described by statistical moment. The main pharmacodynamic parameters were as follows: t_d = 17.79 h, t_{1/2 (ED)} = 3.73 h, AUC = 657.07 U·L^?1·h, MRT = 6.23 h, respectively. Conclusion Xiaoyao Powder used for liver-injured rats shows a rapid absorption, slow elimination process, and longer duration.