前列汤治疗慢性盆腔疼痛综合征湿热瘀阻证临床研究

目的评价前列汤治疗慢性盆腔疼痛综合征(CPPS)湿热瘀阻证的有效性和安全性。方法142例患者随机均分为2组:中药组口服前列汤,每日1剂,分2次服;对照组口服塞来昔布胶囊200mg,每日1次。疗程均为4周。治疗前后检测前列腺按摩液(EPS)中白细胞(WBC)和卵磷脂小体(SPL)计数,进行慢性前列腺炎症状评分(CPSI)及中医证候评分,分析治疗前后的差异并进行两组间比较。结果治疗后中药组CPSI评分较治疗前下降了11分,中医证候积分下降了14.14分,WBC下降了5.86;对照组CPSI评分较治疗前下降了9.85分,中医证候积分下降了9.80分,WBC下降了7.76。两组各项指标治疗前后的差值均有显著统计学意义(P<0.01),两组间差异无统计学意义(P>0.05)。两组治疗后SPL计数分级均明显升高(P<0.01),中药组优于对照组(P<0.01)。两组治疗CPPS湿热瘀阻证的疗效差异无统计学意义(P>0.05)。结论前列汤治疗CPPS湿热瘀阻证有效、安全。

Treatment of chronic pelvic pain syndrome (TCM syndrome of damp-heat and blood-stasis obstruction) with Qianlie Decoction

Objective To evaluate the efficacy and safety of Qianlie Decoction in treating chronic pelvic pain syndrome (CPPS, TCM syndrome of damp-heat and blood-stasis obstruction).Methods The patients (n=142) were randomly divided into the treatment group treated with Qianlie Decoction (1 dose daily taken by 2 times), and the control group was treated with Celecoxib Capsules (200 mg once daily).The treatment course was for 4 weeks in two groups.The count of WBC and SPL in EPS were detected before and after the treatment.The scores of NIH-CPSI and TCM syndromes, and the difference between tow groups were compared and evaluated before and after the treatment.Results After the treatment In the treatment group the scores of NIH-CPSI was induced by 11, scores of TCM syndromes, by 14.14 and WBC, by 5.86.In the control group the scores of NIH-CPSI was induced by 9.85, scores of TCM syndromes,by9.80 and WBC, by 7.76.The difference in all indexes in two groups was statistically significant before and after the treatment (P<0.01).The difference between 2 groups was not significant statistically (P>0.05).SPL counts were all increased significantly in two groups (P<0.01), and the result of the treatment group was better than that of the control group (P<0.01).The difference between two groups in the curative effect on CPPS (TCM syndrome of damp-heat and blood-stasis obstruction) was not statistically significant(P>0.05).Conclusion Qianlie Decoction is efficacious and safe for treating CPPS (TCM syndrome of damp-heat and blood-stasis obstruction).