International consensus statement on the use of disease-modifying agents in multiple sclerosis |
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Authors: | Freedman M S,Blumhardt L D,Brochet B,Comi G,Noseworthy J H,Sandberg-Wollheim M,Soelberg Sørensen P Paris Workshop Group |
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Affiliation: | Multiple Sclerosis Research Clinic, The Ottawa Hospital, Ontario, Canada. mfreedman@ottawahospital.on.ca |
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Abstract: | OBJECTIVE: To provide recommendations on the use of disease-modifying agents in the management of multiple sclerosis (MS) and to ensure that treatment will be available to those patients who may benefit. METHODS: An initial draft of the consensus statement was prepared by the Steering Committee and amended in the light of written comments from a group of MS specialists. At a subsequent workshop, the wording of the consensus statement was discussed, modified if necessary, and the participants indicated their level of support using an electronic voting system. A new draft of the statement was then sent to a much larger group of international opinion leaders in MS for further comment. RESULTS: A number of statements were agreed, which outline the criteria for consideration of disease-modifying therapy for MS and recommendations for treatment. Each statement was accepted completely, or with only minor reservations by 95% or more of those present at the workshop. CONCLUSIONS: Periodic reviews and modifications to the statement will be required, as new approaches to the treatment of MS and other therapeutic agents become available. |
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