健康成人外侧膝状体大小的3.0TMR研究

目的研究正常人外侧膝状体（LGN）的大小，探讨LGN的大小与年龄之间的相关性。方法选取正常志愿者47名，使用GE3.0T磁共振扫描仪，行斜冠状位质子加权成像（PD）和灰白质对比成像序列（GM）扫描，扫描基线垂直于矢状位颞叶及海马体长轴。由两位放射科专家在PD和GM序列图像上记录能观察到LGN的最大层数，并测量LGN的最大高径和体积。结果PD序列测左侧LGN平均最大高径为4.81±0.54mm，平均体积为134.09±25.20mm^3，右侧分别为4.88±0.57mm、135.t34-24.30mm^3;GM序列测左侧LGN平均最大高径为4.58±0.52mm，平均体积为122.53±24.33mm^3，右侧分别为4.66±O.62mm、120.81±22.20mm^3。左侧平均最大层数为3.96±0.41,右侧为4.02±0.44。LGN的最大高径和体积均与年龄呈负相关（P〈0.05），最大层数与年龄无显著相关性（P〉0.05）。结论LGN随年龄增长存在生理性萎缩，在研究各种疾病导致的LGN萎缩时应排除年龄因素干扰。

Relationship between size of lateral geniculate nucleus and age

Objective To study the size of normal lateral geniculate nucleus （LGN） and its relationship with age. Methods 47 healthy volunteers underwent 3 T MRI of the head using the gray matter （GM） and proton density （PD） sequences in the oblique coronal plane perpendicular to the long axis of hippocampus. The number of slices containing the LGN, height and volume of LGN were recorded by two neuroradiologists. Results The average maximum height of LGN was 4.81 ± 0.54 mm on the left and 4.88 ± 0.57 mm on the right on the PD images compared to 4.58 ± 0.52 mm and 4.66 ± 0.62 mm on the GM images, respectively. The average volume of LGN was 134.09 ± 25.20 mm^3 on the left and 135A3±24.30 mm^3 on the right on the PD images compared to 122.53 ± 24.33 mm^3 and 120.81 ± 22.20 mm^3 on the GM images, respectively. The maximum number of slices containing the LGN was 3.96 ± 0.41on the left and 4.02 ±0.44 on the right using both PD and GM sequences. The volume and maximum height of LGN were negatively correlated with the age of volunteers （P 〈 0.05）. There was no significant correlation between the maximum number of slices and age （P 〉 0.05）. Conclusions The LGN decreases in size with aging, which should be considered in the study of diseases with LGN atrophy.