| 替米沙坦在糖尿病防治中的应用 |
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| 引用本文： | 刘涛,崔丽娟,薛欢,牛雅茹,刘子昂,章毅.替米沙坦在糖尿病防治中的应用[J].生命的化学,2021(1):106-112. |
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| 作者姓名： | 刘涛 崔丽娟 薛欢 牛雅茹 刘子昂 章毅 |
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| 作者单位： | 山西医科大学基础医学院药理教研室;山西医科大学细胞生理学重点实验室;山西白求恩医院普通外科;山西医科大学第二临床医学院;山西医科大学第一临床医学院 |
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| 基金项目： | 国家自然科学基金项目(81670710,81973378);山西白求恩医院普通外科“136”兴医工程项目(2019XY015);山西省教育厅优秀研究生创新项目(2019BY078);山西省回国留学人员科研资助项目(2017-053);山西省高等学校大学生创新创业训练计划项目(2019165,2019176)。 |
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| 摘 要： | 替米沙坦是经典的抗血压痛药物.近年来人们发现替米沙坦除可以抑制血管紧张素Ⅱ-1型受体外,还可以部分激活过氧化物酶体增殖物激活受体γ.得益于其双靶点的作用机制,替米沙坦可以通过改善糖脂代谢紊乱和缓解糖尿病带来的并发症而使糖尿病或糖尿病高危病人获益.本文就替米沙坦在糖尿病预防和治疗中的作用及相关的机制研究作一阐述.
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| 关 键 词： | 替米沙坦 糖尿病 血管紧张素Ⅱ-1型受体 过氧化物酶体增殖物激活受体γ |
Application of telmisartan in prevention and treatment of diabetes mellitus |
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| LIU Tao,CUI Lijuan,XUE Huan,NIU Yaru,LIU Ziang,ZHANG Yi.Application of telmisartan in prevention and treatment of diabetes mellitus[J].Chemistry of Life,2021(1):106-112. |
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| Authors: | LIU Tao CUI Lijuan XUE Huan NIU Yaru LIU Ziang ZHANG Yi |
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| Affiliation: | (Department of Pharmacology,School of Basic Medicine,Shanxi Medical University,Taiyuan 030001,China;Key Laboratory of Cellular Physiology,Ministry of Education,Shanxi Medical University,Taiyuan 030001,China;Department of General Surgery,Shanxi Bethune Hospital,Taiyuan 030032,China;Second Clinical Medical College,Shanxi Medical University,Taiyuan 030001,China;First Clinical Medical College,Shanxi Medical University,Taiyuan 030001,China) |
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| Abstract: | Telmisartan is currently used for hypertension. In addition to the inhibition of the angiotensin II type 1(AT-1) receptor, telmisartan has also been reported having the function of partial agonist of the peroxisome proliferator-activated receptor γ(PPARγ). Based on its dual effects, telmisartan can improve the disorder of glucose and lipid metabolism, and alleviate the complications of diabetes, thereby providing benefits for patients with diabetes or pre-diabetes. This review is about the role of telmisartan in the prevention and treatment of diabetes and its related mechanisms. |
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| Keywords: | telmisartan diabetes AT-1 receptor PPARγ |
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