VEGF-C和flt-4在肺腺癌中的表达及其临床意义

目的研究转移相关基因VEGF-C、flt-4在肺腺癌中的表达及其临床意义.方法应用免疫组化方法检测10例正常黏膜组织、10例癌旁组织、56例肺腺癌中的VEGF-C、flt-4的表达情况.结果Flt-4主要在淋巴管内皮细胞中表达.VEGF-C在正常黏膜组织、癌旁组织呈弱阳性反应,在肺腺癌组织中VEGF-C表达强阳性;在高分化组与低分化组之间差异有显著性;且晚期病例VEGF-C表达高于早期病例(P＜0.05);淋巴结转移组VEGF-C阳性率明显高于无淋巴结转移组.VEGF-C高表达组术后3年生存率(23.3%)显著低于低表达组(54.5%,P＜0.05).结论VEGF-C与肺腺癌发生、发展及淋巴结转移、预后密切相关.

Expression and clinical implication of VEGF-C and flt-4 in lung adenocarcinomas

Objective To investgate the expression of VEGF-C and flt-4 in human lung adenocarcinomas and its clinical implication. Methods Immunohistochemical technique was used to examine the expression of VEGF-C and flt-4 of tumor in 56 cases of lung adenocarcinomas, 10 normal lung tissues and 10 normal tissues around the tumor. Results The expression of flt-4 was found to be restricted to the lymphatic endothelial cells. The expression of VEGF-C in cancers was significantly higher than that in 10 normal lung tissues and 10 normal tissues around the tumor. The VEGF-C expression was correlated with clinicopathological grades and lymph node metastasis. In addition, the three-year survival rate of the patients with high expression of VEGF-C was significantly lower than those with low expression. Conclusion VEGF-C promotes growth and metastasis of lung adenocarcinomas and might be one of the predictors for metastasis and prognosis.