| 九头狮子草对发热大鼠体温及下丘脑cAMP含量的影响 |
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| 引用本文： | 覃容贵,李淑芳,罗忠圣. 九头狮子草对发热大鼠体温及下丘脑cAMP含量的影响[J]. 贵阳医学院学报, 2005, 30(1): 53-54,60 |
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| 作者姓名： | 覃容贵 李淑芳 罗忠圣 |
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| 作者单位： | 1. 贵阳医学院,药理学教研室,贵州,贵阳,550004
2. 贵阳新天药业有限公司,贵州,贵阳,550018 |
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| 摘 要： | 目的：研究九头狮子草对发热大鼠的解热作用及对发热大鼠下丘脑cAMP含量的影响，为开发新药源提供药效学依据。方法：复制大鼠酵母人工发热模型，测量大鼠体温变化，用放射免疫法测定大鼠下丘脑cAMP的含量。结果：九头狮子草对发热大鼠有显著解热效应，明显降低发热大鼠下丘脑cAMP含量。结论：九头狮子草有明显的解热作用，其作用可能是通过降低下丘脑体温调节中枢发热介质cAMP含量实现的。
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| 关 键 词： | 发热 下丘脑 植物，药用 小鼠 环磷酸腺苷 九头狮子草 |
| 文章编号： | 1000-2707(2005)01-0053-02 |
Effects of Herba Peristrophis on Temperature and Hypothalamus Camp Content of Feverish Rats |
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| QIN Rong-gui,LI Shu-fang,LUO Zhong-sheng. Effects of Herba Peristrophis on Temperature and Hypothalamus Camp Content of Feverish Rats[J]. Journal of Guiyang Medical College, 2005, 30(1): 53-54,60 |
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| Authors: | QIN Rong-gui LI Shu-fang LUO Zhong-sheng |
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| Affiliation: | QIN Rong-gui 1,LI Shu-fang 1,LUO Zhong-sheng 2 |
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| Abstract: | Objective: To study antipyretic effects of Herba Peristrophis and its effects on cAMP content in the hypothalamus of rats. Methods: Rat models of pyrexia were produced with zymosan. The effects of Herba Peristrophis on fever symptoms were observed. Radioimmunoassay was used to measure the level of cAMP in the rat hypothalamus. Results: Herba Peristrophis evidently decreased temperature and cAMP content in the hypothalamus of rat models. Conclusion: Herba Peristrophis has marked antipyretic effect. The relevant mechanism may be the decreasing of cAMP content in the hypothalamus. The present research provide pharmacological basis for developing new medicine resource. |
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| Keywords: | fever hypothalamus plants medicinal mice cyclic adenosine monophosphate Herba Peristrophis |
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