| 3-乙基-5-吡唑羧酸乙酯的合成研究 |
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| 引用本文： | 刘志勇,叶小东,江洪.3-乙基-5-吡唑羧酸乙酯的合成研究[J].化学试剂,2012,34(1):83-84,87. |
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| 作者姓名： | 刘志勇 叶小东 江洪 |
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| 作者单位： | 1. 江苏剑牌农药化工有限公司,江苏盐城,224700
2. 华中农业大学化学系,湖北武汉,430070 |
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| 摘 要： | 3-乙基-5-吡唑羧酸乙酯是新型杀螨剂吡螨胺的关键中间体,传统的合成方法副反应多、产率低、反应速率慢,探索了用乙酸做催化剂,高效方便地合成了目标产物。同时研究了乙酸做催化剂时合成目标产物的最佳条件。实验结果表明,在丙酰丙酮酸乙酯、乙酸与水合肼的物质的量比为1∶2∶1.2,反应时间4 h,反应温度0～5℃时,收率达到98.53%,纯度达到96.2%。
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| 关 键 词： | 乙酸 催化 吡螨胺 3-乙基-5-吡唑羧酸乙酯 |
Synthesis of ethyl 3-ethyl-5-pyrazolecarboxylate |
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| LIU Zhi-yong
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YE Xiao-dong
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JIANG Hong.Synthesis of ethyl 3-ethyl-5-pyrazolecarboxylate[J].Chemical Reagents,2012,34(1):83-84,87. |
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| Authors: | LIU Zhi-yong YE Xiao-dong JIANG Hong |
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| Affiliation: | 1.Jiangsu Sword Agrochemicals Co.Ltd.,Yancheng 224700,China;2.Department of Chemistry,Huazhong Agricultural University,Wuhan 430070,China) |
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| Abstract: | Ethyl 3-ethyl-5-pyrazolecarboxylate,which is a key intermediate for tebufenpyrad,was synthesized using acetic acid as catalyst in higher yield,faster rate and less by-product than traditional method.The optimal experimental conditions were obtained.Under 0~5 ℃ for 4 h,with a 1∶2∶1.2 molar ratio of ethylpropionylpyruvate,acetic acid and hydrazine hydrate,the optimized yield of 98.53% and purity of 96.2% were obtained. |
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| Keywords: | acetic acid catalyst tebufenpyrad ethyl 3-ethyl-5-pyrazolecarboxylate |
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