晚期恶性肿瘤患者血清肿瘤相关物质的检测与临床应用

目的:探讨晚期恶性肿瘤患者血清肿瘤相关物质（BXTM）含量检测及临床价值。方法:检测250例有复发转移的晚期恶性肿瘤患者、60例无复发转移患者和60例健康体检者血清BXTM含量。结果:晚期恶性肿瘤组BXTM均值为（112.10±20.20）U/ml，阳性率为72.8%。无复发转移患者BXTM均值为（92.35±12.25）U/ml，阳性率为25.0%。正常对照者BXTM均值为（91.28±9.35）U/ml，阳性率为16.7%。复发转移患者血清BXTM含量明显高于无复发转移患者及正常对照者（P<0.05）。无复发转移患者和正常对照者血清BXTM含量无差异（P>0.05）。治疗有效或稳定的患者化疗前血清 BXTM 含量及其阳性率均低于疾病进展的患者（P<0.05）。结论:血清BXTM检测具有较高的敏感性、特异性和广谱性,临床上可用作晚期恶性肿瘤诊断、疗效判断以及随访检测的参考指标。

Detection and application of Bo xin serum tumor associated material(BXTM) in ad-vanced malignant tumor patients

Objective:To investigate the value of the Bo xin serum tumor associated material(BXTM) in the diagnosis of advanced malignant tumors.Methods:With the method of chemical colorimetry，the level of BXTM was determined and compared in 250 cases with advanced malignant tumor，60 cases with early malignant tumor and 60 physical examination volunteers.Results:The mean value of BXTM in advanced malignant tumor patients was （112.10± 20.20）U/ml,and the sensitive rate was 72.8%.The mean value of BXTM in early malignant tumor patients was （92.35±12.25）U/ml,and the sensitive rate was 25.0%.The mean value of BXTM in normal people was （91.28±9.35）U/ml,and the sensitive rate was 16.7%.The levels of BXTM in serum of advanced malignant tumor patients were significantly higher than those of early malignant tumor patients and normal people（P<0.05）.The levels of BXTM in serum of early malignant tumor patients and normal people had no difference(P>0.05）.The levels of BXTM in patients that achieved PR or SD were less than that had PD（P<0.05）.Conclusion:Detecting BXTM in advanced malignant tumor patients has a higher sensitivity，specificity，and wide spectrum.It can be used as the indicator for the diagnosis，treatment effect and follow up in advanced malignant tumors.