| 绵萆薢中两个新二芳基庚酮类化合物的分离和结构鉴定 |
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| 引用本文： | 殷军,刘志惠,王勇,陈英杰,门田重利. 绵萆薢中两个新二芳基庚酮类化合物的分离和结构鉴定[J]. 中国现代中药, 2006, 8(2): 16-19 |
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| 作者姓名： | 殷军 刘志惠 王勇 陈英杰 门田重利 |
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| 作者单位： | 1. 沈阳药科大学中药学院,辽宁,沈阳,110016
2. 富山医科药科大学和汉药研究所,日本,富山,930-0194 |
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| 摘 要： | 目的：研究绵萆薢（Dioscorea spongiosa）的化学成分。方法：利用大孔吸附树脂、硅胶柱层析、制备薄层色谱法进行分离纯化，根据化合物的理化性质和光谱数据鉴定结构。结果：从绵萆薢中分离得到5个化合物，分别鉴定为（3R，5S，7S）-1，7-二苯基-3，7-环氧-5-羟基-1-庚酮（命名为绵萆薢素A，化合物1）、（3S，5S，7S）-1，7-二苯基-3，7-环氧-5-羟基-1-庚酮（命名为绵萆薢素B，化合物2）、（＋）-丁香树脂醇（化合物3）、胡椒醇（化合物4）、芝麻素酮（化合物5）。结论：化合物1、2为新化合物，化合物3、4和5是3个首次从薯蓣属分得的木脂素类化合物。
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| 关 键 词： | 绵萆薢 绵萆薢素A、B 二芳基庚酮 化学成分 结构鉴定 |
| 收稿时间： | 2005-11-15 |
| 修稿时间： | 2005-11-15 |
The isolation and structure identification of two new diarylheptanoids from Dioscorea spongiosa |
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| Yin Jun,Liu Zhihui,Wang Yong,Chen Yingjie and SHIGETOSHI Kadota. The isolation and structure identification of two new diarylheptanoids from Dioscorea spongiosa[J]. Modern Chinese Medicine, 2006, 8(2): 16-19 |
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| Authors: | Yin Jun Liu Zhihui Wang Yong Chen Yingjie SHIGETOSHI Kadota |
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| Affiliation: | School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang Liaoning 110016, China;School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang Liaoning 110016, China;School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang Liaoning 110016, China;School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang Liaoning 110016, China;Institute of Natural Medicines, ToyamaMedical and Pharmaceutical University, Toyama 930-0194, Japan |
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| Abstract: | Objective: To study the chemical constituents of Dioscorea spongiosa. Methods: The compounds wereisolated and purified by macroporous adsorption resin, silica gel column chromatography and preparative TLC chro-matography and their structures were identified on the basis of their physicochemical and spectral data. Results: Fivecompounds were obtained from the CHCl3-MeOH (V:V=10:3) fraction of 90% ethanol extract. Their structures wereelucidated as (3R, 5S, 7S)-1,7-diphenyl-3,7-epoxy-5-hydroxy-1-heptanone (Diospongin A,1), (3S, 5S, 7S) -1,7-diphenyl-3,7-epoxy-5-hydroxy-1-heptanone (Diospongin B,2), ( )-syringaresinol(3), piperitol(4), sesaminone(5).Conclusion: Compounds 1 and 2 are two new diarylheptanoids. Compounds 3, 4 and 5 were obtained from Dioscoreaas three lignans for the first time. |
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| Keywords: | Dioscorea spongiosa Diospongin A, B diarylheptanoid chemical constituents structure elucidation |
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