| 头端延髓腹外侧区注射5—羟色胺对应激性高血粘度... |
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| 引用本文： | 翁可,郭学勤.头端延髓腹外侧区注射5—羟色胺对应激性高血粘度...[J].生理学报,1992,44(3):244-253. |
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| 作者姓名： | 翁可 郭学勤 |
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| 摘 要： |
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| 关 键 词： | 应激 血粘度 血清素 血压 |
Microinjection of 5-HT into the rostral ventrolateral medulla reduced the hyperviscosity and elevation of blood pressure induced by stress] |
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| K Weng,X O Guo,Z J Liang.Microinjection of 5-HT into the rostral ventrolateral medulla reduced the hyperviscosity and elevation of blood pressure induced by stress][J].Acta Physiologica Sinica,1992,44(3):244-253. |
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| Authors: | K Weng X O Guo Z J Liang |
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| Affiliation: | Department of Physiology, Shanghai Medical University. |
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| Abstract: | Experiments were carried out on 62 wistar rats. The hyperviscosity and elevation of blood pressure were induced by hanging and restraining the rats with their four limbs tied on a frame. It was found that microinjection of 5-HT (25 micrograms/10 microliters) into the 4th ventricle of the brain or bilateral microinjection of 5-HT (4 micrograms/0.5 microliters/site) into rostral ventrolateral medulla (rVLM) reduced stress-induced hyperviscosity (p < 0.01) and elevation of blood pressure (p < 0.01). The effect of 5-HT injected into the 4th ventricle or rVLM was blocked by bilateral microinjection of cinanserine (4 micrograms/0.5 microliter/site) into rVLM. These results suggest that microinjection of 5-HT into 4th ventricle and rVLM could reduce stress-induced hyperviscosity and elevation of blood pressure and these effects were probably mediated via 5-HT receptors in the rVLM. |
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