艾司西酞普兰与帕罗西汀治疗单项抑郁症的临床疗效及安全性研究

目的对艾司西酞普兰与帕罗西汀治疗单项抑郁症的疗效及安全性进行分析探讨。方法130例单项抑郁症患者,依据随机数字表法分为对照组与观察组,各65例。对照组采用艾司西酞普兰治疗,观察组采用帕罗西汀治疗。比较两组患者临床疗效、治疗过程中不良反应发生情况、治疗前后抑郁自评量表(SDS)及汉密尔顿抑郁量表(HAMD)评分变化情况。结果观察组患者治疗总有效率89.23%与对照组的87.69%比较,治疗过程中不良反应发生率为18.46%与对照组的21.54%比较,差异均无统计学意义(P>0.05)。治疗后12周,两组患者SDS及HAMD评分均显著低于本组治疗前,差异具有统计学意义(P<0.05);两组患者SDS及HAMD评分比较,差异无统计学意义(P>0.05)。结论对单项抑郁症采用帕罗西汀与艾司西酞普兰治疗均具有疗效确切、安全性高、起效快等优点,临床应用价值较高。

Study the clinical efficacy and safety of escitalopram and paroxetine in the treatment of single depression

Objective To analyze and discuss the efficacy and safety of escitalopram and paroxetine in the treatment of single depression.Methods A total of 130 patients with single depression were divided into control group and observation group according to random numerical table,with 65 cases in each group.The control group was treated with escitalopram,and the observation group was treated with paroxetine.The clinical efficacy,occurrence of adverse reactions during treatment,and changes of self-rating depression scale(SDS)score and Hamilton depression scale(HAMD)score before and after treatment were compared between the two groups.Results The total effective rate of the observation group was 89.23%,which had no statistically significant difference compared with 87.69%of the control group(P>0.05).The incidence of adverse reactions during treatment of the observation group was 18.46%,which had no statistically significant difference compared with 21.54%of the control group(P>0.05).12 weeks after treatment,the SDS and HAMD score of the two groups were significantly lower than those before treatment,and the difference was statistically significant(P<0.05).There was no statistically significant difference in SDS score and HAMD score between the two groups(P>0.05).Conclusion Both paroxetine and escitalopram has the advantages of definite effect,high safety and fast onset in the treatment of single depression,and the clinical application value is high.