In vitro steroid metabolic studies in human testes II: Metabolism of cholesterol, pregnenolone, progesterone, androstenedione and testosterone by testes of an estrogen-treated man |
| |
Authors: | Luis J. Rodriguez-Rigau Robert K. Tcholakian Keith D. Smith Emil Steinberger |
| |
Affiliation: | Department of Reproductive Medicine and Biology The University of Texas Medical School at Houston Houston, Texas, USA |
| |
Abstract: | The effect of long-term in vivo estrogen treatment on in vitro steroidogenesis by the testes of a young man was investigated. In vitro incubation of testicular tissue of this man with 3H-pregnenolone, 3H-progesterone, 3H-androstenedione and 3H-testosterone demonstrated suppression of 17-hydroxylase activity, with little or no effect of the treatment on Δ5-3β-hydroxysteroid oxidoreductase, 5a-reductase and aromatase. Increased 20-hydroxysteroid oxidoreductase activity was observed. Determination of intratesticular steroid concentrations led to similar conclusions. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|