血吸虫病兔胃粘膜微血管超微结构变化

门脉高压性胃粘膜病变是上消化道大出血的原因之一。作者以透射电镜观察,发现血吸虫病兔胃粘膜微血管内皮细胞增生,胞浆增多并突向管腔,使其狭窄,导致粘膜缺血。内皮细胞是再灌注损伤的靶部位,故胃粘膜易发生氧自由基介导的损伤。本研究提示,毛细血管内皮细胞增生是导致晚期血病人胃粘膜微循环障碍的原因之一。

Ultrastructural changes of gastric mucosal microvasculature in rabbits with schistosomiasis

Gastropatht of portal hypertension is another source of upper gastrointestinal hemorrhage. We observed the ultrastructural features of gastric mucosal microvasculature in rabbits with schistosomiasis using transmission electron microscopy. This study showed that the mucosal capillaries have conspicuous endothelial cells, with prominent cytoplasmresulting in reduced capillary luminal area. This could cause mrcosal hypoperfusion and hence be the basis for its increased mucosal susceptibility to damage. The vascular endothelium is the target site of reperfusion. So that the oxygen free radicals can aggravate the injury to gastric mucosa. Our results confirm that the endothelial proliferation may play an important role in the gastric lesions.