| 20-S-原人参二醇组皂苷的制备及其转化制取人参皂苷Rh-2 |
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| 引用本文： | 陈燕萍 孟勤. 20-S-原人参二醇组皂苷的制备及其转化制取人参皂苷Rh-2[J]. 中国药学杂志, 1997, 32(5): 273-275 |
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| 作者姓名： | 陈燕萍 孟勤 |
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| 作者单位： | 长春130021白求恩医科大学基础医学院 |
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| 摘 要： | 目的:制取20(S)-原人参二醇组皂苷并将其转化制备杭癌活性单体20 (S)-人参皂苷-Rh2。方法:以国产西洋参茎叶总皂苷为原料，通过萃取法制备20(S)-原人参二醇组皂苷;将20 (S)-原人参二醇组皂苷碱催化水解后，经柱层析分离纯化制备20(S)-人参皂苷-Rh2。结果:20(S)-原人参二醇组皂苷收率为41.5%，其转化成20(S)-人参皂苷-Rh2的转化率为9.64%.结论:制取方法简便，收率较高。
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| 关 键 词： | 皂苷 西洋参 20(S)-原人参二醇组皂苷 20(S)-人参皂苷-Rh2 |
| 收稿时间： | 1996-08-05; |
Preparation of 20(S )-protopanaxadiol saponins and 20(S)-ginsenoside-Rh2 from 20(S)-protopanaxadiolsaponins |
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| Chen Yanping. Preparation of 20(S )-protopanaxadiol saponins and 20(S)-ginsenoside-Rh2 from 20(S)-protopanaxadiolsaponins[J]. Chinese Pharmaceutical Journal, 1997, 32(5): 273-275 |
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| Authors: | Chen Yanping |
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| Affiliation: | (Chen YP )，Meng Qin ( Meng Q )，Song Changchun(Song CC )，et a |
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| Abstract: | OBJECTIVE: To prepare 20(S)-protopanaxadiol saponins and change them into 20(S)-ginsenoside-Rh2having antitumor activity. METHODS: From the crude saponins of the stems and leaves of American ginseng grown in China, we prepared 20(S)-protopanaxadiol saponins by extraction and 20(S)-ginsenosiok-Rh2 by the alkaline hydrolysis of protopanaxadiol saponins and column chromatography. RESULTS: The yield of 20 (S)-protopanaxadiol saponins was 41.5%，and the yield of 20(S)-ginsenoside-Rh2 was 9.64% from the 20(S)-protopanaxadiol saponins.CONCLUSION: The method is simple and has a high yield. |
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| Keywords: | saponins American ginseng 20(S)-protopanaxadiol saponins 2')" href=" #" > 20-(S)-ginsenoside-Rh2 |
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