超声直方图定量技术在酒精性脂肪肝中医疗效评价中的应用

目的探讨超声直方图定量测定方法在酒精性脂肪肝（AFLD）中医疗效评价中的应用价值。方法选取临床确诊为酒精性脂肪肝（痰瘀互结型）患者60例，随机分成中药组30例，西药组30例，并选取健康志愿者30例为健康对照组，中药组接受以健脾化浊、行气化瘀为主的中医治疗，西药组给予维生素B，、B2、B6及叶酸口服。观察两组患者药物治疗前后肝脏感兴趣区超声直方图灰阶值A及血清学指标（AST、ALT、AST／ALT、GGT）的变化。结果治疗前，中药组、西药对照组间各指标比较差异无统计学意义（P〉0．05）；两组分别与健康对照组比较差异均有统计学意义（P〈0．05）。治疗12周后，中药组灰阶值A、AST、GGT及西药对照组AsT低于治疗前（P〈0．05）；中药组灰阶值A、GGT低于西药对照组（P〈0．05）。结论超声直方图定量测定与血清生化指标在反映酒精性脂肪肝中医疗效上有较好的一致性。

Application of ultrasound histogram quantitative determination in evaluating effect of Chinese medicine on alcoholic fatty liver

Objective To investigate the application of ultrasound histogram quantitative determination in evaluating the effect of Chinese medicine on alcoholic fatty liver （AFLD）. Methods A total of 60 patients diagnosed as alcoholic fatty liver （phlegm-blood stasis） were randomly divided into Chinese medicine group and western medicine group with 30 cases in each. Another 30 healthy people were involved in healthy control group. Patients in Chinese medicine group were treated with Chinese herbal medicine with an effect of invigorating spleen to resolve turbidity and promoting qi to remove stasis, while those in western medicine group were treated by vitamin B1, B 2, B 6, and folic acid. Ultrasound histogram gray-scale value A in the interest region of liver and serum markers （AST, ALT, AST / ALT, and C-＇,GT） in two groups before and after treatment were observed and compared with the healthy control group. Results there was no significant difference in parameters between Chinese medicine group and western medicine group before the treatment（P 〉 O. 05）. Compared with the healthy control group, parameters in both groups have significant difference （P 〈 O. 05）. After twelve-week treatment, ultrasound histogram gray-scale value A, AST, and GGT in Chinese medicine group and ultrasound histogram gray-scale value A in western medicine group were lower than those before treatment, （P 〈0.05 ）, moreover, ultrasound histogram gray-scale value A and GGT in Chinese medicine group were lower than those in western medicine group （P 〈 0.05 ）. Conclusion There is a good consistency between the quantitative determination of ultrasound histogram and the serum markers in the effect of Chinese medicine on AFLD.