| 均匀设计法优选布洛芬缓释原位凝胶剂处方及释药性质的研究 |
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| 引用本文： | 王丽娟,朱照静,吴青,马俐丽.均匀设计法优选布洛芬缓释原位凝胶剂处方及释药性质的研究[J].重庆医科大学学报,2009,34(12). |
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| 作者姓名： | 王丽娟 朱照静 吴青 马俐丽 |
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| 作者单位： | 重庆医科大学药学院药剂教研室,重庆,400016 |
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| 摘 要： | 目的:用均匀设计法筛选布洛芬缓释原位凝胶剂处方,考察不同处方的凝胶溶蚀和药物释放行为.方法:冷法制备原位凝胶,单因素考察布洛芬-羟丙基-β-环糊精包和物和辅料对胶凝温度(T_(sol-gel))的影响,均匀设计法优化P407和P188浓度,无膜溶出法考察凝胶溶蚀行为,高效液相色谱法对溶蚀液进行定量分析.结果:海藻酸钠随浓度的增大可使T_(sol-gel)降低,优化后P407/P188=19%,5%,凝胶溶蚀和药物累积释放与时间均呈零级动力学.结论:均匀设计法适合用于筛选P407和P188浓度,制得的原位凝胶具有缓释效果.
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| 关 键 词： | 均匀设计 泊洛沙姆 原位凝胶 海藻酸钠 无膜溶出 |
Optimization of ibuprofen slowly-released in situ gel by uniform design and studies of release behavior |
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| Abstract: | Objective:To optimize the formula of ibuprofen slowly-released in situ gels and investigate the corrosion of gels and the release of the ibuprofen from the gels.Methods: The in situ gels were prepared by cold method. The effects of IBU-HP- β -CyD and sodium alginate on gelatination temperature (T_(sol-gel)) were investigated. The concentration of P407 and P188 were optimized by uniform design and the corrosion behavior of gels was studied by membraneless model. The fluid of the corrosion was quantitatively analyzed by HPLC. Results: The T_(sol-gel) was degraded with the increase of sodium alginate. The optimized concentration of P407/P188 was 19%/5%. The corrosion of gels and the release of the ibuprofen fitted zero-order kinetics. Conclusion: Uniform design is fit to optimize the concentration of P407 and P188. The gels meet the requirement of sustained-release preparation. |
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| Keywords: | Uniform design Poloxamer In situ gel Sodium alginate Membraneless model |
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