消化道肿瘤患者手术前后肠道通透性检测的临床意义

目的了解消化道肿瘤患者手术治疗前后肠道通透性的改变,探讨肠黏膜屏障功能是否受腹部手术的影响。方法选择手术治疗消化道肿瘤患者16例,在术前、术后1周口服乳果糖、甘露醇液后采集6小时尿样,尿样和乳果糖、甘露醇的标准样经肟化处理后通过气相色谱分析仪糖分子探针法进行检测分析其含量及比值。结果甘露醇峰、乳果糖峰出峰时间稳定,峰面积随含量增加而增加,并且呈线性相关;消化道肿瘤手术前后尿样中的乳果糖含量和乳果糖/甘露醇有显著性差异,乳果糖含量增高,而甘露醇含量手术前后无显著性差异。结论消化道肿瘤手术会导致肠黏膜通透性增加,出现肠黏膜屏障功能损害。

Clinical significance of detecting intestinal permeability of gut tumor patients before and after operation

Objective To assess the intestinal barrier function of the gut tumor patients who had received operation by studying the intestinal permeability.Methods The 16 gut tumor patients were enrolled. After ingestion mannitol and lactulose in de-ionized water before and after operation a week, a 6-hr urine collection was used to analyze their mannitol and lactulose concentration by gas-liquid phase chromatography.Results The lactulose concentration and lactulose/ mannitol (L/M) ratio was increased after operation(P<0.01). Conclusion The intestinal permeability of the gut tumor patients is increased after operation. The operation of the gut tumor patients may induce their intestinal barrier dysfunction. Gas-liquid phase chromatography is a valid method of detecting the intestinal permeability.