The effect of comorbidity on survival and collected CD34 + cell counts in autologous hematopoietic stem cell transplant patients |
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| Affiliation: | 1. ?nönü University, Turgut Özal Medical Center, Adult Hematology Department, Malatya, Turkey;2. ?nönü University, Faculty of Pharmacy, Department of Clinical Pharmacy, Malatya, Turkey;3. ?nönü University, Turgut Özal Medical Center, Department of Internal Medicine, Malatya, Turkey;1. Nam?k Kemal University Medical School, Department of Internal Medicine, Division of Hematology, Tekirdag, Turkey;2. Memorial Bahcelievler Hospital Adult Hematology and BMT Clinic, Istanbul, Turkey;3. Yuzuncu Y?l University Medical School, Department of Internal Medicine, Division of Hematology, Van, Turkey;4. Sanko University Medical School, Department of Internal Medicine, Division of Hematology, Gaziantep, Turkey;5. Mugla S?tk? Kocman University Medical School, Department of Internal Medicine, Division of Hematology, Mugla, Turkey;6. Ege University Medical School, Department of Internal Medicine, Division of Hematology, Izmir, Turkey;7. Medicalpark Hospital, Hematology and BMT Clinic, Izmir, Turkey;8. Celal Bayar University Medical School, Department of Internal Medicine, Division of Hematology, Manisa, Turkey;9. Erciyes University Medical School, Department of Internal Medicine, Division of Hematology, Kayseri, Turkey;10. Hacettepe University Medical School, Department of Internal Medicine, Division of Hematology, Ankara, Turkey;11. Ondokuz Mayis University Medical School, Department of Internal Medicine, Division of Hematology, Samsun, Turkey;12. Dicle University Medical School, Department of Internal Medicine, Division of Hematology, Diyarbakir, Turkey;13. Dokuz Eylul University Medical School, Department of Internal Medicine, Division of Hematology, Izmir, Turkey;1. Department of Pediatrics, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey;2. Department of Pediatric Critical Care Medicine, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey;3. Department of Pediatric Gastroenterology, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey;4. INTERGEN Genetic and Rare Diseases Diagnosis Research and Application Center, Ankara, Turkey;5. Department of Pediatric Endocrinology, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey;1. Division of Transfusion Medicine, Department of Pathology, Microbiology and Immunology. Vanderbilt University Medical Center, 1211 Medical Center Drive, Nashville, TN 37232, USA;2. Vanderbilt Pathology Program in Global Health, Vanderbilt University Medical Center, 1211 Medical Center Drive, Nashville, TN 37232, USA;3. Division of Hematology-Oncology, Department of Internal Medicine, Vanderbilt University Medical Center, 1211 Medical Center Drive, Nashville, TN 37232, USA |
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| Abstract: | ObjectiveIn this study, we aimed to report the effectiveness of hematopoietic cell transplantation–specific comorbidity index (HCT-CI) and GATMO scores in predicting overall survival (OS) who underwent autologous stem cell transplantation (ASCT).Material and methodsThe data of 263 MM and 204 lymphoma patients who underwent ASCT in the last 11 years were retrospectively analyzed.ResultsNeutrophil engraftment time, thrombocyte engraftment time and collected CD34+ cell counts were similar in MM patients with HCT-CI>2 and HCT-CI≤2 (all p>0.05). Although the estimated median OS of MM patients with HCT-CI ≤2 tended to be higher than those with HCT-CI>2, this difference was not statistically significant (52.8 vs 45 months, p=0.172). No effect of GATMO score on CD34 + count, engraftment times and OS in MM patients was detected (p>0.05). The effect of HCT-CI score on lymphoma patients was examined, it was found that the neutrophil engraftment time was longer (p=0.039) and the number of collected CD34+ cells was lower (p=0.02) in patients with HCT-CI>2 than those with HCT-CI≤2. While the estimated median OS of lymphoma patients with HCT-CI≤2 was 51.5 months, the estimated median OS of patients with HCT-CI>2 was 9.5 months (p=0.012). When lymphoma patients were divided into four groups according to their GATMO scores, the OS of the four groups was found to be different from each other (p<0.001).ConclusionHCT-CI and GATMO scores predict OS in lymphoma patients but not MM patients. |
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| Keywords: | Autologous stem cell transplantation Lymphoma Multiple myeloma Hematopoietic cell transplantation-specific comorbidity index Engraftment time |
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