| 离子束注入抗生素产生菌诱变效应的研究 |
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| 引用本文： | 谢立青 张培灵. 离子束注入抗生素产生菌诱变效应的研究[J]. 核技术, 1995, 18(6): 324-330 |
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| 作者姓名： | 谢立青 张培灵 |
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| 作者单位： | 北京市辐射中心，北京师范大学低能核物理研究所，北京第二制药厂 |
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| 摘 要： |
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| 关 键 词： | 抗生素 制备 菌种 菌种诱变 诱变效应 离子注入 |
A study on mutagenic effects of antibiotic-producers by ion implantation |
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| Xie Liqing,Zhang Yinfen,Chen Ruyi,Zhou Ruiying. A study on mutagenic effects of antibiotic-producers by ion implantation[J]. Nuclear Techniques, 1995, 18(6): 324-330 |
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| Authors: | Xie Liqing Zhang Yinfen Chen Ruyi Zhou Ruiying |
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| Abstract: | Mutagenic effects of Streptomyces ribosidificus,Streptomyces kanamyceticus and the phage-resistant culture of Streptomyces kanamyceticus induced by N+ and C+ ion implantation with different doses have been investigated.The experimental results show that the death rates of antibiotic-producers increase with the increase of ion implantation dose, and the form mutation of the antibiotic-producers is rather obvious. After N+ ion implantation,the titer units increase by 10%-25%, 5.2%12.1% and 2.1%-12.75% for the above three strains respectively; while after C+ion implantation the titer units increase by 10%-16.9%,1.05%-3.08% and 5%-20% respectively.The selected strains of Micromonospora echimospoora and Streptomyces kanamyceticus after N+ ion implantation have been used in the factory.The increase of production is 20% and 12.5% respectively, showing marked economic benefits are obtained. |
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| Keywords: | Ion implantation Antibiotic-producers Mutagenesis Form mutation Titer |
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