造血干细胞移植患者预防性抗真菌治疗

目的 为比较具菌药物对造血干移植患者真菌感染的预防效果。方法 对１２８例移植患者预防应用抗真菌药物的临床疗效进行分析；分３组：酮康唑０．２每日１次口服３０例，酮康唑０．２每日１次口服，同时加大蒜素２￣３粒，每日３次口服或３０￣６０ｍｇ，每日１次静脉点滴３６例，氟康唑５０￣１００ｍｇ每日１次口服６２例。结果 单作酮康唑组真菌感染率为４３．３％，真菌血症１０％；酮康唑与大蒜素合用组真菌感染率为４７．２

Clinical Trial of Prophylactic Antifungal Therapy in Patients Undergoing Hematopoietic Stem Cell Transplantation

OBJECTIVE The effects of prophylactic antifungal therapy were retrospectively evaluated in 128 patients undergoing hematopoietic stem cell transplantation(HSCT). METHODS The patients were divided into three groups according to different drugs used,ie,ketoconazole, ketoconazole plus Allium sativum and fluconazole. RESULTS In 30 patients taking ketoconazole alone,in 13(43.3%) were found fungal infections,including 3(10%) with fungal septicemia. In 36 patients receiving besides A satirvum ketoconazole plus, fungal infection was found in 17(47.2%),including 4(11.1%) with fungal septicemia.In fluconazole group(62 patients),9(14.5%)suffered from fungal infection,2(3.2%) of which were fungal septicemia.Candidiasis was the most frequent type in fungal infection.CONCLUSIONS 1.Fluconazole has better clinical effects on prevention of fungal infection than ketoconazole.2.Prophylactic use of A sativum does not decrease fungal infection.3.Candida infection is still the most common fungal infection in patients undergoing HSCT.