| 灵芝多糖对家兔缺血再灌注时血液抗氧化能力的影响 |
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| 引用本文： | 陈洁,杨红梅,裴瑞,王黎.灵芝多糖对家兔缺血再灌注时血液抗氧化能力的影响[J].河南职工医学院学报,2005,17(2):75-77. |
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| 作者姓名： | 陈洁 杨红梅 裴瑞 王黎 |
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| 作者单位： | 河南职工医学院,河南,郑州,450003;河南职工医学院,河南,郑州,450003;河南职工医学院,河南,郑州,450003;河南职工医学院,河南,郑州,450003 |
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| 摘 要： | 目的探讨灵芝多糖(GLP)对家兔缺血再灌注过程中脂质过氧化反应的影响。方法将家兔分为对照组(生理盐水组)、实验组(灵芝多糖组),建立低血容量性休克动物模型。分别于休克前、休克40min及再灌注40min后测定血清超氧化物歧化酶(SOD)及丙二醛(MDA)含量。结果实验组再灌注40min后,SOD活性高于对照组(P<0.01),MDA含量低于对照组(P<0.01)。结论GLP对缺血再灌注损伤具有保护作用。
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| 关 键 词： | 灵芝多糖 缺血-再灌注损伤 超氧化物歧化酶 丙二醛 氧自由基 家兔 |
| 文章编号： | 1008-9276(2005)02-0075-03 |
| 修稿时间： | 2005年3月11日 |
Effect of GLP on the Anti-lipid Peroxidation Ability of Rabbit with Ischemia-reperfusion Injury |
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| CHEN Jie,YANG Hong-mei,PEI Rui,WANG Li.Effect of GLP on the Anti-lipid Peroxidation Ability of Rabbit with Ischemia-reperfusion Injury[J].Journal of Henan Medical College For Staff and Workers,2005,17(2):75-77. |
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| Authors: | CHEN Jie YANG Hong-mei PEI Rui WANG Li |
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| Abstract: | Objective To study the effect of GLP on the ability of anti-lipid peroxidation of rabbit with IRI(ischemia-reperfusion injury).Methods Rabbits were randomly divided into control group(n=8) and GLP injection group(n=8).With a hemorrhagic shock model,the content of superoxide dismutase(SOD)and malondialdehyde(MDA)in blood serum were measured before hemorrhagic shock,40 minutes before after reperfusion respectively.WTHZ]Results The SOD level of GLP group was higher than that of control group 40 minutes after reperfusion(P<0.01).The MDA level of GLP group was lower than the control group 40 minutes after reperfusion(P<0.01).Conclusion GLP can prevent tissue from ischemia-reperfusion injury. |
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| Keywords: | Ganoderma Lucidum Polysaccharide ischemia-reperfusion injury superoxide dismutase malo-naldehyde oxygen free radicals rabbit |
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