| 3-溴-1-(3-氯-2-吡啶基)-1H-吡唑-5-甲酸的合成研究 |
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| 引用本文： | 刘健,匡滨海,隋双明,王令东,闫玉刚,李少华.3-溴-1-(3-氯-2-吡啶基)-1H-吡唑-5-甲酸的合成研究[J].当代化工,2011,40(1):11-13,17. |
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| 作者姓名： | 刘健 匡滨海 隋双明 王令东 闫玉刚 李少华 |
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| 作者单位： | 1. 南昌大学,江西,南昌,330006
2. 江西省皮肤病专科医院,江西,南昌,330001 |
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| 摘 要： | 3-溴-1-(3-氯-2-吡啶基)-1H-吡唑-5-甲酸是合成新型鱼尼丁受体杀虫剂氯虫酰胺(chlorantraniliprole)的关键中间体.以2,3-二氯吡啶为原料通过肼基取代、马来酸二乙酯环合、对甲基苯磺酰氯酯化、溴化氢溴化、浓硫酸氧化脱氢以及水解6步反应制得3-溴-1-(3-氯-2-吡啶基)-1H-吡唑-5-...
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| 关 键 词： | 2 3-二氯吡啶 3-溴-1-(3-氯-2-吡啶基)-1H-吡唑-5-甲酸 氯虫酰胺 |
Synthesis of 3-Bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5- carboxylic Acid |
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| LIU Jian,KUANG Bin-hai,SUI Shuang-ming,WANG Ling-dong,YAN Yu-gang,LI Shao-hua.Synthesis of 3-Bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5- carboxylic Acid[J].Contemporary Chemical Industry,2011,40(1):11-13,17. |
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| Authors: | LIU Jian KUANG Bin-hai SUI Shuang-ming WANG Ling-dong YAN Yu-gang LI Shao-hua |
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| Affiliation: | LIU Jian1,KUANG Bin-hai1,SUI Shuang-ming2,WANG Ling-dong1,YAN Yu-gang1,LI Shao-hua(1.Nanchang University,Jiangxi Nanchang 330006,China,2.Jiangxi Provincial Hospital for Skin Diseases,Jiangxi Nanchang 330001,China) |
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| Abstract: | 3-Bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid is an important intermediate of a new insecticide chlorantraniliprole.Taking 2,3-dichloropyridine as raw material,3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyra-zole-5-carboxylic acid was synthesized via hydrazino-substitution,diethyl maleate-cyclization,pyrazolidinecarboxylate-esterification,bromide hydrogen-bromination,concentrated sulfuric acid oxidative dehydrogenation and hydrolysis.The results show that the raw material of this reaction is easil... |
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| Keywords: | 2 3-dichloropyridine 3-Bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid Chlorantraniliprole |
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