The potential of microelectrode arrays and microelectronics for biomedical research and diagnostics |
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Authors: | Ian L Jones Paolo Livi Marta K Lewandowska Michele Fiscella Branka Roscic Andreas Hierlemann |
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Affiliation: | 1.Department Biosystems Science and Engineering (BSSE),Eidgen?ssische Technische Hochschule Zürich (ETHZ),Basel,Switzerland |
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Abstract: | Planar microelectrode arrays (MEAs) are devices that can be used in biomedical and basic in vitro research to provide extracellular
electrophysiological information about biological systems at high spatial and temporal resolution. Complementary metal oxide
semiconductor (CMOS) is a technology with which MEAs can be produced on a microscale featuring high spatial resolution and
excellent signal-to-noise characteristics. CMOS MEAs are specialized for the analysis of complete electrogenic cellular networks
at the cellular or subcellular level in dissociated cultures, organotypic cultures, and acute tissue slices; they can also
function as biosensors to detect biochemical events. Models of disease or the response of cellular networks to pharmacological
compounds can be studied in vitro, allowing one to investigate pathologies, such as cardiac arrhythmias, memory impairment
due to Alzheimer’s disease, or vision impairment caused by ganglion cell degeneration in the retina. |
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