贵州省小儿氟骨症骨转换机制的动态研究

本文报告了在环境流行病学调查的基础上，用病区粮食及燃煤进行大鼠氟中毒模型的复制，进一步探讨不同类型氟骨症的影响因素及发病机制，为制订有针对性的防治措施提供科学依据。实验用Wistar大鼠180只，随机分为6组，即高氟组、高氟加营养组、低氟组、低氟加营养组、煤烟污染组及对照组。结果表明，除对照组外，其余各组均出现氟斑牙．骨蛎X光片及病理组织学检查，高氟组出现骨疏松，并伴有骨转换征象，加营养可减轻骨病变程度，呼吸道吸入氟也可引起氟骨症，但病变较轻。引起不同类型氟骨症的主要因素是总摄氟量高、营养低下（蛋白质及钙摄入不足）和铝元素增多等。

STUDY ON THE PATHOGENESIS OF OSTEO-TRANSFORMATION IN CHILDREN''S SKELETAL FLUOROSIS

In order to go further into the influential factors and the pathogenesis of different types of skeletal fluorosis, andprovide scientific basis for working out effective measures to prevent and treat fluorosis, animal model of fluorosis was inducedwith food and high fluoride content coal burning of the endemic area based on the survey of environmental epidemiology before. Inthis experiment, 180 wistar rats were divided into 6 groups, namely. (1) high dose fluoride, (2) high dose fluoride with nutrientsuppliment, (3) low dose fluoride, (4) low dose fluoride with nutrient suppliment, (5) pollution of coal burning, (6) control.The results showed that all rats except those of control group had dental fluorosis. By means of skeletal roentgenoscopy and pathological determinations osteoporosis followed abnormal osteo-transformation was found in rats of group 1. The supplementation ofnutrients is beneficial to reduce skeletal fluorosis. Fluoride absorbed by respiratory tract can also cause skeletal fluorosis, but it wasless serious. The main influential factors which led up to various types of skeletal fluorosis are total fluoride intake, malnutrition(protein and calcium insufficiency) and high intake of alnuminium compounds, etc.