日本血吸虫与HBV感染协同致肝癌作用的研究

以血吸虫病流行地区和非流行地区常住居民1175人为对象，用ELISA法检测HBV、HCV血清学标志，用快速双抗体夹心ELISA检测抗体判断血吸虫感染。结果，流行地区感染率分别为：HBV（63．8％）、抗-HCV（2．2％），血吸虫（70．2％）；非流行地区感染率分别为HBV（49．7％），抗-HCV（0．9％），血吸虫（5．2％）。共检测490人血吸虫抗体，阳性176人（35．9％），阳性者HBV、HCV、肝硬变率显著高于阴性者。HBV、HCV，血吸中两种以上合并感染，均较单独感染对肝功能及肝硬变影响大，合并感染比上述感染阴性者的肝硬变患病率增长3．7－7．1倍，并发现HBV与血吸虫感染有相加致癌作用。

A STUDY OF HEPATOCELLULAR CARCINOMA ON SYNERGY AMONG THE COMBINED INFECTIONS OF SCHISTOSOMIASIS AND HBV

A survey both on schistosomiasis endemic and non-endemic areas with 1 175 persons was carried out from November 1992 to November 1994. The results showed that infection rates of HBV,anti-HCV and schistosomiasis were 63. 8%, 2. 2% and 70. 2% respectively in the endemic area,and were 49. 7 %, 0. 9 % and 5. 2 % respectively in the non-endemic area. Of all 490 persons who had been tested for infection of schistosomiasis by ELISA method, 176persons were positive. The infection rates of HBV,HCV and the incidence of cirrhosis were higher in the schistosomiasis positive persons than that in the negative persons. The combined infections of HBV, HCV and schistosomiasis may have more negative effects on the function of liver and cirrhosis than the single infection may have. The relative risk in the combined infection people was 3. 7- 7. 1 times higher than that in the uninfectied people. And the infections of HBV and schistosomiasis may have an additive on hepatocellular carcinoma.