| 还原型谷胱甘肽预防奥沙利铂所致神经毒性的临床观察 |
| |
| 引用本文： | 苑珩珩,白玉贤,孙秀威,周建华,韩宇,魏孝礼.还原型谷胱甘肽预防奥沙利铂所致神经毒性的临床观察[J].实用临床医药杂志,2011,15(11):47-50. |
| |
| 作者姓名： | 苑珩珩 白玉贤 孙秀威 周建华 韩宇 魏孝礼 |
| |
| 作者单位： | 哈尔滨医科大学附属第三医院,黑龙江,哈尔滨,150040 |
| |
| 摘 要： | 目的探讨用还原型谷胱甘肽(GSH)预防及减轻奥沙利铂(OXL)引起急慢性神经毒性的临床应用价值。方法 106例结肠癌术后使用FOLFOX4方案辅助化疗的患者,随机分为两组,一组在使用OXL化疗前后给予GSH,另一组不给予GSH,观察两组患者急慢性神经毒性的发生率和发生程度,分析两组患者的中位无进展生存时间(PFS)是否有差异。结果急性神经毒性在试验组总的发生率为88.8%,对照组为90.3%(P值=0.801),两组间差异无统计学意义。慢性神经毒性治疗组总发生率为88.9%,显著低于对照组的100%(P<0.05),随着OXL累积剂量的增加,神经毒性的发生率也增加。治疗组与对照组中位随访46.0个月和46.5个月后,中位PFS分别为51.8个月与49.2个月(P值=0.848),差异无统计学意义。结论在OXL治疗前后使用GSH可以减轻慢性神经毒性的发生率和程度,而对急性神经毒性无影响。GSH不影响OXL的治疗疗效,对患者的中位PFS无影响。
|
| 关 键 词： | 结肠癌 奥沙利铂 神经毒性 还原型谷胱甘肽 预防 |
Clinical observation of the prevention against neurotoxicity related to Oxaliplatin with use of reduced glutathione |
| |
| YUAN Heng-heng,BAI Yu-xian,SUN Xiu-wei,ZHOU Jian-hua,HAN Yu,WEI Xiao-li.Clinical observation of the prevention against neurotoxicity related to Oxaliplatin with use of reduced glutathione[J].Journal of Clinical Medicine in Practice,2011,15(11):47-50. |
| |
| Authors: | YUAN Heng-heng BAI Yu-xian SUN Xiu-wei ZHOU Jian-hua HAN Yu WEI Xiao-li |
| |
| Affiliation: | YUAN Heng-heng,BAI Yu-xian,SUN Xiu-wei,ZHOU Jian-hua,HAN Yu,WEI Xiao-li(The Third Hospital Affiliated to Harbin Medical University Harbin,Heilongjiang,150040) |
| |
| Abstract: | Objective To explore the clinical application value of reduced Glutathione(GSH) to prevent and mitigate acute or chronic neurotoxicity with Oxaliplatin(OXL).Methods 106 patients of colon cancer adjuvant therapy with FOLFOX4 were randomly divided into two groups.In the treatment group,the patients were treated with GSH before and after using OXL;in the control group,the patients were treated without the use of GSH.The incidence and occurrence of acute and chronic neurotoxicity between the two groups were obs... |
| |
| Keywords: | Oxaliplatin neurotoxicity reduced glutathione prevention |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
