氯沙坦钾氢氯噻嗪片治疗T2DM合并高血压的临床分析

目的观察氯沙坦钾氢氯噻嗪片治疗2型糖尿病（Type 2Diabetes Mellitus，T2DM）合并高血压的临床效果及安全性。方法将86例T2DM合并高血压患者按照数字表法随机分为两组，对照组采用氯沙坦钾片联合氢氯噻嗪片治疗；观察组则采用氯沙坦钾氢氯噻嗪片复合制剂治疗，并比较两组疗效。结果观察组的总有效率（95．35％）明显高于对照组（81．40％）（P〈0．05）．两组患者治疗前SBP、DBP相比较差异均无统计学意义（P〉0．05），两组患者治疗后SBP、DBP与治疗前比较差异有统计学意义（P〈0．05），观察组治疗后的SBP、DBP明显低于对照组（均P〈0．05），对照组患者治疗后FPG、P2hBG较前升高（P〈0．05），观察组患者治疗前后FPG、P2hBG无明显变化（P〉0．05）；观察组治疗后FPG、P2hBG与对照组比较差异有统计学意义（均P〈0．05）。结论氯沙坦钾氢氯噻嗪片治疗T2DM合并高血压患者降压效果疗效肯定、起效快、作用强、安全性高、不良反应少，而且对血糖影响小，有利于提高患者服药依从性。

Clinical analysis on losartan potassium and hydrochlorothiazide tablets treating type 2 diabetes mellitus with hypertention

Objective To observe the clinical curative effect and safety of losartan potassium and hydrochlorothiazide tablets on treating type 2 diabetic mellitus with hypertension. Methods 86 patients with type 2 diabetic mellitus and hypertension were divided into the test group and the control group with the method of randomized controlled trials according to randomized controlled table. The control group was treated with losartan potassium tablets and hydrochlorothiazide tablets. The test group was treated with losartan potassium and hydrochlorothiazide tablets. Finally, the clinical curative effects were compared. Results In the total efficiency, the test group was 95.35%, the control group was 81.40%, the test group was significantly better than the control group （P 〈 0.05）. Systolic blood pressure and diastolic blood pressure before treatment had no statistical significant difference （/9 〉 0.05）. Systolic blood pressure and diastolic blood pressure after treatment of the two group was lower than that before treatment （P 〈 0.05）. Systolic blood pressure and diastolic blood pressure of the test group was lower than that of the control group （P 〈 0.05）, FPG and P2hBG after treatment of the control group increased, the other groups had no significant changes. The test group was better than the control group （P 〈 0.05）. Conclusion Losartan potassium and hydrochlorothiazide tablets on treating type 2 diabetic mellitus with hypertension has efficient, fast and strong curative effect, with higher safety and less adverse reactions. Losartan potassium and hydrochlorothiazide tablets has less influence on blood glucose. It can improve patients＇ drug therapy compliance.