枸地氯雷他定联合维生素D滴剂治疗慢性自发性荨麻疹的疗效观察

 目的 观察枸地氯雷他定联合维生素D滴剂治疗血清25-(OH)维生素D含量缺乏的慢性自发性荨麻疹患者的临床疗效。方法 选取2018-10至2019-09就诊于山西医科大学第一医院皮肤科门诊的血清25-(OH)维生素D含量缺乏的慢性自发性荨麻疹患者108例,按随机数字表法分为两组,每组54例。对照组予口服枸地氯雷他定片,治疗组予口服枸地氯雷他定片联合维生素D滴剂,疗程均为6周,比较两组患者的总有效率及治疗前后的每天发作次数评分、每天发作时间评分、皮肤病生活质量指数评分、血清25-(OH)维生素D含量的差异。结果 治疗后治疗组总有效率83.33%,高于对照组的64.81%,差异有统计学意义(P＜0.05);治疗前两组各项指标差异均无统计学意义,治疗后两组各项指标均较治疗前有改善,差异有统计学意义(P＜0.05);治疗后治疗组每天发作次数评分、每天发作时间评分及DLQI评分均低于对照组,差异均有统计学意义(P＜0.05);治疗组25-(OH)维生素D含量明显高于对照组,差异有统计学意义;治疗后治疗组平均血清25-(OH)维生素D含量(59.43±10.08)nmol/L]与对照组血清25-(OH)维生素D含量(30.19±9.60)nmol/L]相比差异有统计学意义(P＜0.05)。结论 血清25-(OH)维生素D含量缺乏的慢性自发性荨麻疹患者口服枸地氯雷他定片联合维生素D滴剂疗效显著,能够改善患者的生活质量,值得推广使用。

Efficacy of deloratadine citrate disodium tablets combined with vitamin D drops against chronic idiopathic urticaria

Objective To observe the clinical efficacy of desloratadine citrate disodium tablets combined with vitamin D drops against chronic spontaneous urticaria patients with serum 25- (OH) VD deficiency.Methods One hundred and eight outpatients with chronic spontaneous urticaria complicated with a deficiency of serum 25- (OH) VD content who were treated in the Dermatology Department of the First Hospital of Shanxi Medical University between October 2018 and September 2019 were divided into two groups using the random number table method: the control group (54 cases) that was given oral desloratadine citrate disodium tablets alone, and the observation group (54 cases) that was treated with oral desloratadine citrate disodium tablets combined with vitamin D drops. The course of treatment was 6 weeks. The total effective rate of patients, daily episode number scores, daily episode time scores, Dermatological Quality of Life Index (DLQI) scores and serum 25-(OH)VD content before and after treatment were compared between the two groups.Results The total effective rate in the observation group after treatment was 83.33%, higher than that in the control group (64.81%). The difference between the two groups was statistically significant(P＜0.05). After treatment, the mean serum 25-(OH)VD content(59.43±10.08)nmol/L] in the observation group was significantly different from that of the control group(30.19±9.60)nmol/L](P＜0.05).Conclusions In the clinical treatment of chronic spontaneous urticaria patients with a deficiency of serum 25- (OH) VD content , oral deloratadine citrate disodium tablets alone or in combination with vitamin D drops have good curative effect, but the latter approach is more effective in that it can significantly improve the therapeutic effect and patients’ quality of life, which should be made more accessible in future clinical use.