肿瘤标记物联合检测对肺癌诊断的价值 |
| |
引用本文: | 余秉翔,胡斌,陈良安.肿瘤标记物联合检测对肺癌诊断的价值[J].解放军医学杂志,2003,28(4):354-355. |
| |
作者姓名: | 余秉翔 胡斌 陈良安 |
| |
作者单位: | 1. 100853,北京,解放军总医院 2. 安徽铜陵市人民医院 |
| |
摘 要: | 探讨联合检测癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)、细胞角蛋白片段(CYFRA2l—1)在肺癌诊断中的应用价值。应用放射免疫法分别检测75例肺癌患者和22例肺良性疾病患者血清中CEA、NSE、CYFRA21—l水平。结果显示,CEA在肺腺癌中的水平最高,NSE在肺小细胞癌中的水平最高,CYFRA2l—l在肺鳞癌中的水平最高。CEA NSE CYFRA2l—1联合检测肺癌的阳性率为82.67%。提示CEA、NSE、CYFRA2l—l 3项指标联合检测可提高肺癌诊断的阳性率。
|
关 键 词: | 肿瘤标记物 联合 检测 肺癌 诊断 |
修稿时间: | 2002年12月5日 |
THE CLINICAL SIGNIFICANCE OF TUMOR MARKERS COMBINATION MEASUREMENT IN DIAGNOSIS OF LUNG CANCER |
| |
Abstract: | To study the clinical significance of combined measurement of neuron specific enolase(NSE), carcinoembryonic antigen(CEA) and Cytokeratin19 fragment 21 1 (CYFRA 21 1 ) in the diagnosis of lung cancer. The serum levels of CEA, NSE, and CYFRA 21 1 in 75 lung cancer patients as well as in 22 benign pulmonary diseases patients were measured by radioimmunoassay. Patients with pulmonary adenocarcinoma had a highest CEA level. Small cell lung carcinoma (SCLC) patients had a highest NSE level, while patients with squamous cell carcinoma of lung had a highest CYFRA 21 1 level. The positive rate of the combination of CEA, NSE, and CYFRA 21 1 for lung cancers was 82 67%. The results suggested that the combined measurement of CEA, NSE, and CYFRA 21 1 was helpful in the diagnosis of lung cancer. |
| |
Keywords: | lung neoplasms biological markers diagnosis |
本文献已被 CNKI 维普 万方数据 等数据库收录! |
|