颈动脉狭窄与肿瘤坏死因子-α及白介素6的相关性分析

目的探讨缺血性脑血管病患者颈动脉狭窄与肿瘤坏死因子-α(TNF-α)及白介素6(IL-6)的相关性。方法选择128例缺血性脑血管病患者于入院后测定血清TNF-α、IL-6水平,均行数字减影全脑血管造影(DSA)检查,再根据DSA结果将缺血性脑血管病患者分为颈动脉正常组(27例)、轻度狭窄组(34例)、中度狭窄组(31例)和重度狭窄组(36例),并进行对照分析。结果各狭窄组患者血浆TNF-α、IL-6水平均显著高于无狭窄组(P<0.01),重度狭窄组TNF-α、IL-6水平明显高于中度狭窄组和轻度狭窄组患者(P<0.05),中度狭窄组明显高于轻度狭窄组(P<0.05)。结论血清TNF-α、IL-6是血管炎症的标志物,其水平与颈动脉狭窄程度呈正相关,在临床诊断及病情判断上具有重要价值。

The correlation analysis between tumor necrosis factor-α, interleukin-6 levels and carotid artery stenosis

Objective To get the correlation between carotid artery stenosis and plasma tumor necrosis factor-α （TNF-α） , the interleukin 6 （IL-6）by investigating patients with ischemic cerebrovascular disease. Methods Choosing 128 cases of patients with isehemic cerebrovascular disease for the study. All patients were hospitalized after the determination of plasma of TNF-α, IL-6 level and underwent digital subtraction cerebral angiography （DSA） examination. According to the DSA results, patients with isehemie eerebrovascular disease were divided into normal carotid artery （27 cases）, mild stenosis group （34cases）, moderate stenosis group （31 cases） and severe stenosis group （36 cases ）. The comparative analysis were made between different groups. Results By comparing the average level of serum of TNF-α, and IL-6 water, patients in the stenosis group was significantly higher than the non-stenosis group＇s （ P 〈 0.01 ）. Patients in the severe stenosis group was significantly higher than the moderate stenosis and mild stenosis group ＇s （ P 〈 0.05 ）. And moderate stenosis group＇s patient was significantly higher than the mild stenosis group＇s （ P 〈 0.05 ）. Conclusion TNF-α, IL-6 is a marker of vascular inflammation. Its level is positively correlated with carotid artery stenosis, which is of great value in the judgment of the clinical diagnosis and progression.