缺血性卒中患者颈动脉斑块与内皮素-1及丙二醛水平的相关性分析

目的 探讨急性缺血性卒中患者颈动脉粥样硬化斑块与血浆内皮素-1（endothelin-1，ET-1）及丙二醛 （malondialdehyde，MDA）水平的关系。 

Correlation of Endothelin-1 and Malondialdehyde with Carotid Plaques in Patients with Ischemic Stroke

Objective To investigate the correlation between carotid plaques and endothelin-1 (ET-1) and
malondialdehyde (MDA) in patients with acute ischemic stroke.
Methods Carotid ultrasonography was performed in 118 patients with acute ischemic stroke. All
patients were divided into normal intima group (n =12), intima thickening group (n =28) and plaque
group (n =78). The plaque group was divided into plaque I (n =21), plaque II (n =25) and plaque III
(n =32). The plasma ET-1 and MDA level were measured in each group. The correlation of ET-1 and
MDA with plaque formation was analyzed.
Results The level of plasma ET-1 in normal, thickening intima and plaque groups were (2.34±0.27) ng/L,
(3.96±0.38) ng/L and (6.23±0.42) ng/L, respectively; and the level of plasma MDA in the three
groups were (4.20±0.48) nmol/ml, (6.18±0.52) nmol/ml and (8.37±0.65) nmol/ml, respectively. The
level of plasma ET-1 (P =0.036, P =0.031) and MDA (P =0.046, P =0.022) in plaque group and intima
thickening group were significantly higher than that in normal intima group; and both ET-1 and
MDA in plaque group were higher than that in intima thickening group (P =0.040, P =0.034). With
the severity of plaque increasing, the plasma ET-1 and MDA levels gradually increased (P =0.041,
P =0.037).
Conclusion Plasma ET-1 and MDA levels are associated with carotid atherosclerosis and its
severity in patients with acute ischemic stroke.