正常范围同型半胱氨酸不同水平与复发性脑梗死的相关性研究

目的 探讨正常范围同型半胱氨酸（homocysteine，Hcy）水平与复发性脑梗死之间的关系。 

Correlation between Normal Homocysteine Levels and Recurrent Cerebral Infarction

Objective To investigate the relationship between normal homocysteine (Hcy) levels and recurrent
cerebral infarction.
Methods 600 patients with acute cerebral infarction from the First Affiliated Hospital of Henan
University of Traditional Chinese Medicine from June 2015 to June 2017 were included in this study.
According to the pathogenesis, all the patients were divided into large artery atherosclerosis group,
cerebral embolism group and cerebral small artery occlusion group. According to medical history, the
patients were divided into first stroke group and recurrent stroke group. 200 inpatients without acute
cerebrovascular diseases during the same period were selected as control group. The plasma Hcy
levels of different groups were compared. The proportion of high-normal Hcy level (10 μmol/L < Hcy
< 15 μmol/L) in the first and recurrent stroke groups were compared.
Results The level of Hcy in large artery atherosclerosis group, cerebral embolism group, cerebral
small artery occlusion group were significantly different with that in control group (P <0.05).
The proportion of high-normal Hcy level in first stroke group (25.4%) was lower than that in
recurrent stroke group (35.1%), and the difference was statistically significant (χ 2=6.171, P =0.013).
Multivariate logistic regression analysis showed that high-normal Hcy level and hypertension were
independent risk factors of recurrent cerebral infarction.
Conclusions The high-normal Hcy level is one of risk factors of recurrent cerebral infarction.Effective control of Hcy level in patients with cerebral infarction is a new approach of secondary
prevention for ischemic stroke.