妊娠相关蛋白-A与冠心病病变程度相关性及PCI术后的变化

目的 探讨妊娠相关蛋白-A(PAPP-A)与冠状动脉病变程度关系及在经皮冠状动脉介入治疗(PCI)后的变化.方法 42例冠心病患者,分为急性心肌梗死(AMI)组12例、不稳定型心绞痛(UAP)组15例和稳定型心绞痛(SAP)组15例,均行经冠状动脉造影(CAG)确诊,其中24例行PCI术,16例CAG结果正常者为对照...

Relationship between pregnancy-associated plasma protein A and the severity of coronary lesions in patients with coronary heart disease and their changes after percutaneous coronary intervention

Objective To investigate the relationship between pregnancy-associated plasma protein A（PAPP-A）and the severity of coronary lesions in patients with coronary heart disease （CHD）and their＇changes after percutaneous coronary intervention（PCI ）. Methods 42 patients with CHD were divided into the acute myocardial infarction （ AMI ）group （n = 12 ）, the unstable angina pectoris （ UAP ） group （n = 15 ） and the stable angina pectoris （SAP） group （n=lS）, by coronary angiography （CAG）, 24 cases were received PCI and 16 normal subjects without CHD diagnosed by CAG served as the control group. The serum level of PAPP-A measured by enzyme linked immunosorbent assay （ELISA）. The relationships between PAPP-A and the severity of stenosis, stenosis number and their changes after PCI were analyzed. Results The mean level of serum PAPP-A was obviously higher in the AMI and UAP group compared with SAP and control group （P〈0.01）, but there were no significant differences in AMI group and UAP group （P〉0.05）. The mean level of serum PAPP-A in the SAP group than in the control group was no significant differences （P〉0.05）. There were no significant differences of PAPP-A among the single vessel lesion group,the double vessel lesion group and three vessel lesion group （P〉0.05）. The mean level after PCI was higher than those before PCI （P〈0.O1）. Conclusion PAPP-A may play a role in the occurrence and development of atheromatous plaque of the patients with AMI and UAP, and probably act as one of the biomarkers of vulnerable plaques, and may concern with restenosis after PCI.