| p16基因突变与子宫内膜癌关系的研究 |
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| 引用本文： | 张秋实,其木格,李继俊.p16基因突变与子宫内膜癌关系的研究[J].肿瘤防治研究,2003,30(1):23-25. |
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| 作者姓名： | 张秋实 其木格 李继俊 |
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| 作者单位： | 1. 250021,济南,山东省立医院、山东大学临床医学院妇产科
2. 内蒙古医学院第一附属医院妇产科 |
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| 摘 要： | 目的 研究 p16基因的突变在子宫内膜癌发生、发展中的作用。 方法 应用PCR SSCP及DNA测序对 4 0例子宫内膜癌中 p16基因第二外显子缺失及序列改变进行研究。 结果 4 0例子宫内膜癌中 12例存在 p16基因的第二外显子 5 2 2bp的纯合缺失 ,10例存在点突变 (突变位点相同 ) ,突变位点之一为第 12 6密码子硷基GTC→AAT(错义突变 ) ,另一突变位点为第 12 7密码子GCA→GCG(同义突变 ) ,缺失及突变共占 5 5 %。结论 p16基因的突变与子宫内膜癌的发生有明显的相关性。
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| 关 键 词： | p16基因 突变 子宫内膜癌 |
| 文章编号： | 1000-8578(2003)01-0023-03 |
| 收稿时间： | 2002-1-20 |
| 修稿时间： | 2002年1月20日 |
Study on the relationship between the mutations of p16 gene and endometrial carcinoma |
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| ZHANG Qiu shi,QI Mu ge,LI Ji jun Dept. of Obstet and Gynecol,Shandong Province Hospital,Jinan ,China.Study on the relationship between the mutations of p16 gene and endometrial carcinoma[J].Cancer Research on Prevention and Treatment,2003,30(1):23-25. |
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| Authors: | ZHANG Qiu shi QI Mu ge LI Ji jun Dept of Obstet and Gynecol Shandong Province Hospital Jinan China |
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| Affiliation: | ZHANG Qiu shi,QI Mu ge,LI Ji jun Dept. of Obstet and Gynecol,Shandong Province Hospital,Jinan 250021,China |
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| Abstract: | Objective To study the relationship between the alterations of p16 gene and the occurrence and development of the endometrial carcinoma.Methods The alterations of p16 gene were studied by ploymerase chain reaction single strand conformation polymorphism(PCR SSCP) and DNA sequencing in 40 endometrial carcinomas. Results The exon 2 of p16 gene occurred 522bp homozygous deletion in 12 cases. The point mutations at the same site were detected in 10 cases, and one of mutating sites was GTC→AAT(Val126Asn) on... |
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| Keywords: | p16 gene Mutation Endometrial carcinoma |
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